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dc.creatorStanić, Dušanka
dc.creatorPlećaš-Solarović, Bosiljka
dc.creatorPetrović, Jelena
dc.creatorBogavac-Stanojević, Nataša
dc.creatorSopić, Miron
dc.creatorKotur-Stevuljević, Jelena
dc.creatorIgnjatović, Svetlana
dc.creatorPešić, Vesna
dc.date.accessioned2019-09-02T11:54:57Z
dc.date.available2019-09-02T11:54:57Z
dc.date.issued2016
dc.identifier.issn0009-2797
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2704
dc.description.abstractContemporary lifestyle is commonly associated with chronic stress, an environmental factor contributing to development of various psychological and somatic disorders. Increased levels of glucocorticoids, observed in the chronic stress, induce the production of reactive oxygen species leading to genotoxicity. The aim of this study was to investigate whether chronic administration of oxytocin (OXY) 10 IU/400 mu L/day, s.c., for 14 days, a hormone presumed to exert antioxidant effect, may prevent DNA damage in the comet assay of peripheral blood lymphocytes of Wistar rats treated chronically with corticosterone (CORT) 100 mg/L ad libitum, per os, for 21 days, as well as, to influence some plasma oxidative stress parameters, i.e. levels of total lipid hydroperoxide (LOOH), and malondialdehyde (MDA), and the activity of antioxidative enzyme superoxide dismutase (SOD). Even though there was no reduction in overall number of damaged cells after oxytocin treatment only, the marked increase in total comet score (TCS) after incubation with H2O2 in CORT group compared to controls, was absent in the CORT + OXY experimental group. Furthermore, significant decrease of highly damaged cells compared to corticosterone group was noted. Chronic oxytocin administration thus protected lymphocytes from high intensity damage that leads to cellular death. In addition, treatment with OXY along with CORT, significantly decreased concentration of LOOH in plasma, and increased SOD compared to CORT treatment only. This finding corresponds well with current reports on beneficial effects of OXY in conditions of HPA axis hyperactivity, and supports the hypothesis of OXY-mediated antioxidant action.en
dc.publisherElsevier Ireland Ltd, Clare
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS//
dc.rightsrestrictedAccess
dc.sourceChemico-Biological Interactions
dc.titleHydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatmenten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПлећаш-Соларовић, Босиљка; Богавац-Станојевић, Наташа; Пешић, Весна; Петровић, Јелена; Игњатовић, Светлана; Сопић, Мирон; Станић, Душанка; Котур-Стевуљевић, Јелена;
dc.citation.volume256
dc.citation.spage134
dc.citation.epage141
dc.citation.other256: 134-141
dc.citation.rankM21
dc.identifier.wos000382341100015
dc.identifier.doi10.1016/j.cbi.2016.07.006
dc.identifier.pmid27402529
dc.identifier.scopus2-s2.0-84978374810
dc.identifier.rcubconv_3654
dc.type.versionpublishedVersion


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