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Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women

Korelacija fibrinogena sa kardiometaboličkim faktorima rizika kod predgojaznih/gojaznih žena u postmenopauzi

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2016
2707.pdf (549.1Kb)
Authors
Klisić, Aleksandra
Kotur-Stevuljević, Jelena
Kavarić, Nebojša
Jovanović, Milovan
Škerović, Verica
Article (Published version)
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Abstract
Higher fibrinogen levels may play an important role in cardiovascular diseases in postmenopausal women. Previous studies have reported its higher levels in obese individuals, as compared with normal weight counterparts. However, the mechanism of the relationship between fibrinogen and cardiometabolic risk factors is not well elucidated. Therefore, we aimed to examine this relationship in overweight/obese postmenopausal women. Methods: A total of 100 overweight/obese postmenopausal women were included in this study. Blood pressure and anthropometric parameters: height, weight and waist circumference were measured, and body mass index (BMI) was calculated in all participants. Biochemical parameters: fibrinogen, glycemia, (insulin resistance (HOMA-IR) was calculated) and lipid profile (total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, triglycerides/HDLcholesterol ratio, non-HDL-cholesterol) were determined. Results: After dividing patients according to tertile values of ...fibrinogen concentration, significant increase in BMI (P=0.039), waist circumference (P=0.002), insulin (P=0.005), HOMA-IR (P=0.006), triglycerides (P=0.001), triglycerides/HDL-c ratio (P=0.002) and non-HDL-c (P=0.014) were found in the second and the third fibrinogen tertile, as compared with the first, the lowest level fibrinogen tertile. In multiple linear regression analysis, HOMAIR (Beta=0.225; p=0.007) and triglycerides (Beta=0.188; p=0.023), (R2=0.213; p lt 0.001) were the best predictors of higher fibrinogen level. Conclusion: Fibrinogen may be a useful marker in determining cardiovascular risk in obese postmenopausal women.

Visoke vrednosti fibrinogena mogu imati važnu ulogu u nastanku kardiovaskularnih bolesti, koje su vodeći uzrok smrtnosti kod žena u postmenopauzi. Ranije studije su pokazale više vrednosti fibrinogena kod gojaznih, u poređenju sa normalno uhranjenim osobama. Ipak, nedovoljno je rasvetljen mehanizam povezanosti fibrinogena sa kardiometaboličkim faktorima rizika koji prate gojaznost. Zato je cilj ove studije bio da se ispita ova povezanost u populaciji predgojaznih/gojaznih žena u postmenopauzi. Metode: U ovom istraživanju je bilo uključeno 100 predgojaznih/gojaznih žena u postmenopauzi. Svim ispitanicama meren je krvni pritisak i izvršena su antropometrijska merenja koja su obuhvatila merenje telesne visine, telesne mase i obima struka; izračunat je i indeks telesne mase (ITM). Određivani su sledeći biohemijski parametri: fibrinogen, glikemija, (insulinska rezistencija (HOMA-IR) je izračunata), lipidni status (ukupni holesterol, trigliceridi, LDL-holesterol, HDL-holesterol, odnos trigli...ceridi/HDL-holesterol, non-HDL-holesterol). Rezultati: Podelom fibrinogena na tercilne vrednosti, u drugoj i trećoj tercilnoj grupi uočene su više vrednosti ITM (P=0,039), obima struka (P=0,002), insulina (P=0,005), HOMA-IR (P=0,006), trigliceridi (P=0,001), odnos trigliceridi/HDL-holesterol (P=0,002) i non- HDL-holesterol (P=0,014) u poređenju sa prvom tercilnom grupom, tj. grupom sa najnižim vrednostima fibrinogena. Primenom višestruke linearne regresije, najveći uticaj na varijabilitet fibrinogena pokazali su HOMA-IR (beta=0,225; p=0,007) i nivo triglicerida (beta=0,188; p=0,023), (R2=0,213; p lt 0,001). Zaključak: Fibrinogen može biti koristan marker za procenu kardiometaboličkog rizika kod gojaznih žena u postmenopauzi.

Keywords:
inflammation / fibrinogen / obesity / cardiometabolic risk / menopause / inflamacija / fibrinogen / gojaznost / kardiometabolički rizik / menopauza
Source:
Timočki medicinski glasnik, 2016, 41, 2, 83-90
Publisher:
  • Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar

DOI: 10.5937/tmg1602083K

ISSN: 0350-2899

[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2709
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
AU  - Škerović, Verica
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2709
AB  - Higher fibrinogen levels may play an important role in cardiovascular diseases in postmenopausal women. Previous studies have reported its higher levels in obese individuals, as compared with normal weight counterparts. However, the mechanism of the relationship between fibrinogen and cardiometabolic risk factors is not well elucidated. Therefore, we aimed to examine this relationship in overweight/obese postmenopausal women. Methods: A total of 100 overweight/obese postmenopausal women were included in this study. Blood pressure and anthropometric parameters: height, weight and waist circumference were measured, and body mass index (BMI) was calculated in all participants. Biochemical parameters: fibrinogen, glycemia, (insulin resistance (HOMA-IR) was calculated) and lipid profile (total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, triglycerides/HDLcholesterol ratio, non-HDL-cholesterol) were determined. Results: After dividing patients according to tertile values of fibrinogen concentration, significant increase in BMI (P=0.039), waist circumference (P=0.002), insulin (P=0.005), HOMA-IR (P=0.006), triglycerides (P=0.001), triglycerides/HDL-c ratio (P=0.002) and non-HDL-c (P=0.014) were found in the second and the third fibrinogen tertile, as compared with the first, the lowest level fibrinogen tertile. In multiple linear regression analysis, HOMAIR (Beta=0.225; p=0.007) and triglycerides (Beta=0.188; p=0.023), (R2=0.213; p lt 0.001) were the best predictors of higher fibrinogen level. Conclusion: Fibrinogen may be a useful marker in determining cardiovascular risk in obese postmenopausal women.
AB  - Visoke vrednosti fibrinogena mogu imati važnu ulogu u nastanku kardiovaskularnih bolesti, koje su vodeći uzrok smrtnosti kod žena u postmenopauzi. Ranije studije su pokazale više vrednosti fibrinogena kod gojaznih, u poređenju sa normalno uhranjenim osobama. Ipak, nedovoljno je rasvetljen mehanizam povezanosti fibrinogena sa kardiometaboličkim faktorima rizika koji prate gojaznost. Zato je cilj ove studije bio da se ispita ova povezanost u populaciji predgojaznih/gojaznih žena u postmenopauzi. Metode: U ovom istraživanju je bilo uključeno 100 predgojaznih/gojaznih žena u postmenopauzi. Svim ispitanicama meren je krvni pritisak i izvršena su antropometrijska merenja koja su obuhvatila merenje telesne visine, telesne mase i obima struka; izračunat je i indeks telesne mase (ITM). Određivani su sledeći biohemijski parametri: fibrinogen, glikemija, (insulinska rezistencija (HOMA-IR) je izračunata), lipidni status (ukupni holesterol, trigliceridi, LDL-holesterol, HDL-holesterol, odnos trigliceridi/HDL-holesterol, non-HDL-holesterol). Rezultati: Podelom fibrinogena na tercilne vrednosti, u drugoj i trećoj tercilnoj grupi uočene su više vrednosti ITM (P=0,039), obima struka (P=0,002), insulina (P=0,005), HOMA-IR (P=0,006), trigliceridi (P=0,001), odnos trigliceridi/HDL-holesterol (P=0,002) i non- HDL-holesterol (P=0,014) u poređenju sa prvom tercilnom grupom, tj. grupom sa najnižim vrednostima fibrinogena. Primenom višestruke linearne regresije, najveći uticaj na varijabilitet fibrinogena pokazali su HOMA-IR (beta=0,225; p=0,007) i nivo triglicerida (beta=0,188; p=0,023), (R2=0,213; p lt 0,001). Zaključak: Fibrinogen može biti koristan marker za procenu kardiometaboličkog rizika kod gojaznih žena u postmenopauzi.
PB  - Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar
T2  - Timočki medicinski glasnik
T1  - Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women
T1  - Korelacija fibrinogena sa kardiometaboličkim faktorima rizika kod predgojaznih/gojaznih žena u postmenopauzi
VL  - 41
IS  - 2
SP  - 83
EP  - 90
DO  - 10.5937/tmg1602083K
ER  - 
@article{
author = "Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Kavarić, Nebojša and Jovanović, Milovan and Škerović, Verica",
year = "2016",
abstract = "Higher fibrinogen levels may play an important role in cardiovascular diseases in postmenopausal women. Previous studies have reported its higher levels in obese individuals, as compared with normal weight counterparts. However, the mechanism of the relationship between fibrinogen and cardiometabolic risk factors is not well elucidated. Therefore, we aimed to examine this relationship in overweight/obese postmenopausal women. Methods: A total of 100 overweight/obese postmenopausal women were included in this study. Blood pressure and anthropometric parameters: height, weight and waist circumference were measured, and body mass index (BMI) was calculated in all participants. Biochemical parameters: fibrinogen, glycemia, (insulin resistance (HOMA-IR) was calculated) and lipid profile (total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, triglycerides/HDLcholesterol ratio, non-HDL-cholesterol) were determined. Results: After dividing patients according to tertile values of fibrinogen concentration, significant increase in BMI (P=0.039), waist circumference (P=0.002), insulin (P=0.005), HOMA-IR (P=0.006), triglycerides (P=0.001), triglycerides/HDL-c ratio (P=0.002) and non-HDL-c (P=0.014) were found in the second and the third fibrinogen tertile, as compared with the first, the lowest level fibrinogen tertile. In multiple linear regression analysis, HOMAIR (Beta=0.225; p=0.007) and triglycerides (Beta=0.188; p=0.023), (R2=0.213; p lt 0.001) were the best predictors of higher fibrinogen level. Conclusion: Fibrinogen may be a useful marker in determining cardiovascular risk in obese postmenopausal women., Visoke vrednosti fibrinogena mogu imati važnu ulogu u nastanku kardiovaskularnih bolesti, koje su vodeći uzrok smrtnosti kod žena u postmenopauzi. Ranije studije su pokazale više vrednosti fibrinogena kod gojaznih, u poređenju sa normalno uhranjenim osobama. Ipak, nedovoljno je rasvetljen mehanizam povezanosti fibrinogena sa kardiometaboličkim faktorima rizika koji prate gojaznost. Zato je cilj ove studije bio da se ispita ova povezanost u populaciji predgojaznih/gojaznih žena u postmenopauzi. Metode: U ovom istraživanju je bilo uključeno 100 predgojaznih/gojaznih žena u postmenopauzi. Svim ispitanicama meren je krvni pritisak i izvršena su antropometrijska merenja koja su obuhvatila merenje telesne visine, telesne mase i obima struka; izračunat je i indeks telesne mase (ITM). Određivani su sledeći biohemijski parametri: fibrinogen, glikemija, (insulinska rezistencija (HOMA-IR) je izračunata), lipidni status (ukupni holesterol, trigliceridi, LDL-holesterol, HDL-holesterol, odnos trigliceridi/HDL-holesterol, non-HDL-holesterol). Rezultati: Podelom fibrinogena na tercilne vrednosti, u drugoj i trećoj tercilnoj grupi uočene su više vrednosti ITM (P=0,039), obima struka (P=0,002), insulina (P=0,005), HOMA-IR (P=0,006), trigliceridi (P=0,001), odnos trigliceridi/HDL-holesterol (P=0,002) i non- HDL-holesterol (P=0,014) u poređenju sa prvom tercilnom grupom, tj. grupom sa najnižim vrednostima fibrinogena. Primenom višestruke linearne regresije, najveći uticaj na varijabilitet fibrinogena pokazali su HOMA-IR (beta=0,225; p=0,007) i nivo triglicerida (beta=0,188; p=0,023), (R2=0,213; p lt 0,001). Zaključak: Fibrinogen može biti koristan marker za procenu kardiometaboličkog rizika kod gojaznih žena u postmenopauzi.",
publisher = "Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar",
journal = "Timočki medicinski glasnik",
title = "Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women, Korelacija fibrinogena sa kardiometaboličkim faktorima rizika kod predgojaznih/gojaznih žena u postmenopauzi",
volume = "41",
number = "2",
pages = "83-90",
doi = "10.5937/tmg1602083K"
}
Klisić, A., Kotur-Stevuljević, J., Kavarić, N., Jovanović, M.,& Škerović, V.. (2016). Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women. in Timočki medicinski glasnik
Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar., 41(2), 83-90.
https://doi.org/10.5937/tmg1602083K
Klisić A, Kotur-Stevuljević J, Kavarić N, Jovanović M, Škerović V. Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women. in Timočki medicinski glasnik. 2016;41(2):83-90.
doi:10.5937/tmg1602083K .
Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Kavarić, Nebojša, Jovanović, Milovan, Škerović, Verica, "Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women" in Timočki medicinski glasnik, 41, no. 2 (2016):83-90,
https://doi.org/10.5937/tmg1602083K . .

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