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Korelacija fibrinogena sa kardiometaboličkim faktorima rizika kod predgojaznih/gojaznih žena u postmenopauzi

dc.creatorKlisić, Aleksandra
dc.creatorKotur-Stevuljević, Jelena
dc.creatorKavarić, Nebojša
dc.creatorJovanović, Milovan
dc.creatorŠkerović, Verica
dc.date.accessioned2019-09-02T11:55:05Z
dc.date.available2019-09-02T11:55:05Z
dc.date.issued2016
dc.identifier.issn0350-2899
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2709
dc.description.abstractHigher fibrinogen levels may play an important role in cardiovascular diseases in postmenopausal women. Previous studies have reported its higher levels in obese individuals, as compared with normal weight counterparts. However, the mechanism of the relationship between fibrinogen and cardiometabolic risk factors is not well elucidated. Therefore, we aimed to examine this relationship in overweight/obese postmenopausal women. Methods: A total of 100 overweight/obese postmenopausal women were included in this study. Blood pressure and anthropometric parameters: height, weight and waist circumference were measured, and body mass index (BMI) was calculated in all participants. Biochemical parameters: fibrinogen, glycemia, (insulin resistance (HOMA-IR) was calculated) and lipid profile (total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, triglycerides/HDLcholesterol ratio, non-HDL-cholesterol) were determined. Results: After dividing patients according to tertile values of fibrinogen concentration, significant increase in BMI (P=0.039), waist circumference (P=0.002), insulin (P=0.005), HOMA-IR (P=0.006), triglycerides (P=0.001), triglycerides/HDL-c ratio (P=0.002) and non-HDL-c (P=0.014) were found in the second and the third fibrinogen tertile, as compared with the first, the lowest level fibrinogen tertile. In multiple linear regression analysis, HOMAIR (Beta=0.225; p=0.007) and triglycerides (Beta=0.188; p=0.023), (R2=0.213; p lt 0.001) were the best predictors of higher fibrinogen level. Conclusion: Fibrinogen may be a useful marker in determining cardiovascular risk in obese postmenopausal women.en
dc.description.abstractVisoke vrednosti fibrinogena mogu imati važnu ulogu u nastanku kardiovaskularnih bolesti, koje su vodeći uzrok smrtnosti kod žena u postmenopauzi. Ranije studije su pokazale više vrednosti fibrinogena kod gojaznih, u poređenju sa normalno uhranjenim osobama. Ipak, nedovoljno je rasvetljen mehanizam povezanosti fibrinogena sa kardiometaboličkim faktorima rizika koji prate gojaznost. Zato je cilj ove studije bio da se ispita ova povezanost u populaciji predgojaznih/gojaznih žena u postmenopauzi. Metode: U ovom istraživanju je bilo uključeno 100 predgojaznih/gojaznih žena u postmenopauzi. Svim ispitanicama meren je krvni pritisak i izvršena su antropometrijska merenja koja su obuhvatila merenje telesne visine, telesne mase i obima struka; izračunat je i indeks telesne mase (ITM). Određivani su sledeći biohemijski parametri: fibrinogen, glikemija, (insulinska rezistencija (HOMA-IR) je izračunata), lipidni status (ukupni holesterol, trigliceridi, LDL-holesterol, HDL-holesterol, odnos trigliceridi/HDL-holesterol, non-HDL-holesterol). Rezultati: Podelom fibrinogena na tercilne vrednosti, u drugoj i trećoj tercilnoj grupi uočene su više vrednosti ITM (P=0,039), obima struka (P=0,002), insulina (P=0,005), HOMA-IR (P=0,006), trigliceridi (P=0,001), odnos trigliceridi/HDL-holesterol (P=0,002) i non- HDL-holesterol (P=0,014) u poređenju sa prvom tercilnom grupom, tj. grupom sa najnižim vrednostima fibrinogena. Primenom višestruke linearne regresije, najveći uticaj na varijabilitet fibrinogena pokazali su HOMA-IR (beta=0,225; p=0,007) i nivo triglicerida (beta=0,188; p=0,023), (R2=0,213; p lt 0,001). Zaključak: Fibrinogen može biti koristan marker za procenu kardiometaboličkog rizika kod gojaznih žena u postmenopauzi.sr
dc.publisherSrpsko lekarsko društvo - Podružnica Zaječar, Zaječar
dc.rightsopenAccess
dc.sourceTimočki medicinski glasnik
dc.subjectinflammationen
dc.subjectfibrinogenen
dc.subjectobesityen
dc.subjectcardiometabolic risken
dc.subjectmenopauseen
dc.subjectinflamacijasr
dc.subjectfibrinogensr
dc.subjectgojaznostsr
dc.subjectkardiometabolički riziksr
dc.subjectmenopauzasr
dc.titleCorrelation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal womenen
dc.titleKorelacija fibrinogena sa kardiometaboličkim faktorima rizika kod predgojaznih/gojaznih žena u postmenopauzisr
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКлисић, Aлександра; Јовановић, Милован; Котур-Стевуљевић, Јелена; Шкеровић, Верица; Каварић, Небојша; Корелација фибриногена са кардиометаболичким факторима ризика код предгојазних/гојазних жена у постменопаузи; Корелација фибриногена са кардиометаболичким факторима ризика код предгојазних/гојазних жена у постменопаузи;
dc.citation.volume41
dc.citation.issue2
dc.citation.spage83
dc.citation.epage90
dc.citation.other41(2): 83-90
dc.citation.rankM52
dc.identifier.doi10.5937/tmg1602083K
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1358/2707.pdf
dc.identifier.rcubconv_718
dc.type.versionpublishedVersion


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