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Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats
dc.creator | Đekić, Ljiljana | |
dc.creator | Martinović, Martina | |
dc.creator | Stepanović-Petrović, Radica | |
dc.creator | Micov, Ana | |
dc.creator | Tomić, Maja | |
dc.creator | Primorac, Marija | |
dc.date.accessioned | 2019-09-02T11:55:13Z | |
dc.date.available | 2019-09-02T11:55:13Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0928-0987 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2714 | |
dc.description.abstract | The study investigated usage of hydrogel of an anionic polymer xanthan gum for design of ibuprofen-loaded hydrogel-thickened microemulsions (HTMs) from the nonionic oil-in-water microemulsion (M). Xanthan gum demonstrated the performances of a thickening agent in physically stable HTMs at 5 +/- 3 degrees C, 20 +/- 3 degrees C, and 40 +/- 1 degrees C during 6 months. The results of physicochemical characterization (pH, conductivity, rheological behaviour, spreadability) indicated that HTMs containing 0.25-1.00% of the polymer had colloidal structure with oil nanodroplets of 1434 +/- 0.98 nm (PdI 0220 +/- 0.075) dispersed in aqueous phase thickened with the polymer gel network which strength depended on the polymer concentration. HTMs with ibuprofen (5%) were evaluated as percutaneous drug delivery carriers. In vitro ibuprofen release from HTMs followed zero order kinetic (r > 0.995) for 12 h, while the referent hydrogel was described by Higuchi model. The HTM with optimized drug release rate and spreadability (HTM1) and the polymer-free microemulsion (M) were assessed and compared with the referent hydrogel in in vivo studies in rats. HTM1 and M were significantly more efficacious than reference hydrogel in producing antihyperalgesic and at lower extent antiedematous activity in prophylactic topical treatment protocol, whilst they were comparable in producing antihyperalgesic/antiedematous effects in therapeutic protocol. Topical treatments produced no obvious skin irritation. | en |
dc.publisher | Elsevier Science BV, Amsterdam | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS// | |
dc.rights | restrictedAccess | |
dc.source | European Journal of Pharmaceutical Sciences | |
dc.title | Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Приморац, Марија; Степановић-Петровић, Радица; Ђекић, Љиљана; Томић, Маја; Мицов, Aна; Мартиновић, Мартина; | |
dc.citation.volume | 92 | |
dc.citation.spage | 255 | |
dc.citation.epage | 265 | |
dc.citation.other | 92: 255-265 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000381833900028 | |
dc.identifier.doi | 10.1016/j.ejps.2016.05.005 | |
dc.identifier.pmid | 27157041 | |
dc.identifier.scopus | 2-s2.0-84971591986 | |
dc.type.version | publishedVersion |