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dc.creatorGrujić, Maja
dc.creatorPopović, Marija
dc.creatorPopović, Gordana
dc.creatorNikolić, Katarina
dc.creatorAgbaba, Danica
dc.date.accessioned2019-09-02T11:55:14Z
dc.date.available2019-09-02T11:55:14Z
dc.date.issued2016
dc.identifier.issn0022-3549
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2715
dc.description.abstractProtolytic equilibria of irbesartan, losartan, and valsartan have been investigated in the presence and absence of differently charged anionic (sodium dodecyl sulfate), cationic (cetyltrimethylammonium bromide), and nonionic (4-octylphenol polyethoxylate and polyoxyethylene (23) lauryl ether) surfactants. Ionization constants were determined by potentiometric titration at a constant ionic strength (0.1 M NaCl) and temperature 25 degrees C. The effect of surfactants was estimated, based on a shift in apparent ionization constants (pK(a)(app)) determined in micellar solutions against the pK(a)(w) values in water. The anionic surfactant caused an increase in the pK(a)(app) values of sartans (up to 1.72 pK units), while the cationic surfactant had an opposite effect and caused a reduction in pK(a)(app) values (up to -1.44 pK units). These results point out to the fact that the ionizable groups of sartans are involved in electrostatic interactions with the charged surface of the ionic micelles. Shift in the pKa app values in the presence of nonionic surfactants (from -0.86 to +1.30) is a consequence of the interactions of drugs with the hydrophilic palisade layer. Significant changes in the distribution profiles of the equilibrium forms (from -44% to +80%) are observed at the biopharmaceutically important pH 4.5 value and can be considered in terms of the potential influence on intestinal absorption and bioavailability.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172033/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmaceutical Sciences
dc.titleProtolytic Equilibria of Sartans in Micellar Solutions of Differently Charged Surfactantsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПоповић, Марија; Грујић, Маја; Aгбаба, Даница; Николић, Катарина; Поповић, Гордана;
dc.citation.volume105
dc.citation.issue8
dc.citation.spage2444
dc.citation.epage2452
dc.citation.other105(8): 2444-2452
dc.citation.rankM22
dc.identifier.wos000381770400025
dc.identifier.doi10.1016/j.xphs.2016.06.007
dc.identifier.pmid27422089
dc.identifier.scopus2-s2.0-84978929438
dc.identifier.rcubconv_3650
dc.type.versionpublishedVersion


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