Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes
Authorized Users Only
2016
Authors
Miljković, Milica
Kotur-Stevuljević, Jelena

Stefanović, Aleksandra

Zeljković, Aleksandra

Vekić, Jelena

Gojković, Tamara

Bogavac-Stanojević, Nataša

Nikolić, Milan

Simić-Ogrizović, Sanja

Spasojević-Kalimanovska, Vesna

Jelić-Ivanović, Zorana

Article (Published version)

Metadata
Show full item recordAbstract
Unfavorable lipid profile is a major risk factor for cardiovascular disease in renal pathology. In this study, we compared chronic renal patients and healthy controls with different LDL phenotypes (A or B) in respect of various biochemical parameters related to cardiovascular disease. Oxidative stress and anti-oxidative defense parameters [thiobarbituric acid-reacting substances (TBARS), total oxidative status (TOS), total anti-oxidative status (TAS), total protein sulfhydryl (-SH) groups], as well as red blood cell cholesterol distribution were assessed in 40 renal patients and 40 control subjects by standardized assays. LDL particle diameters were determined by polyacrylamide gradient gel electrophoresis. LDL particles are subdivided according to their size into large LDL A phenotype (diameter > 25.5 nm) and small LDL B phenotype (diameter aecurrency sign25.5 nm). Renal patients with LDL A phenotype had increased oxidative stress (TOS: p lt 0.01, and TBARS: p lt 0.001) and decrea...sed total SH- groups (p lt 0.001) compared to controls with the same LDL phenotype. A notable decrease in hemoglobin-cholesterol adduct was detected in patients with LDL A phenotype (p lt 0.001) and LDL B phenotype (p lt 0.05) compared with appropriate controls. LDL B phenotype was characterized with increased TBARS (p lt 0.05) compared with LDL A phenotype in control group. Increased oxidative stress, decreased anti-oxidative defense followed with unfavorable changes in hemoglobin-cholesterol binding capacity, could have important influence on cardiovascular disease risk in renal patients regardless of LDL phenotype.
Source:
International Urology and Nephrology, 2016, 48, 10, 1683-1690Publisher:
- Springer, Dordrecht
Funding / projects:
DOI: 10.1007/s11255-016-1358-0
ISSN: 0301-1623
PubMed: 27412679
WoS: 000384563100019
Scopus: 2-s2.0-84978148560
Collections
Institution/Community
PharmacyTY - JOUR AU - Miljković, Milica AU - Kotur-Stevuljević, Jelena AU - Stefanović, Aleksandra AU - Zeljković, Aleksandra AU - Vekić, Jelena AU - Gojković, Tamara AU - Bogavac-Stanojević, Nataša AU - Nikolić, Milan AU - Simić-Ogrizović, Sanja AU - Spasojević-Kalimanovska, Vesna AU - Jelić-Ivanović, Zorana PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2724 AB - Unfavorable lipid profile is a major risk factor for cardiovascular disease in renal pathology. In this study, we compared chronic renal patients and healthy controls with different LDL phenotypes (A or B) in respect of various biochemical parameters related to cardiovascular disease. Oxidative stress and anti-oxidative defense parameters [thiobarbituric acid-reacting substances (TBARS), total oxidative status (TOS), total anti-oxidative status (TAS), total protein sulfhydryl (-SH) groups], as well as red blood cell cholesterol distribution were assessed in 40 renal patients and 40 control subjects by standardized assays. LDL particle diameters were determined by polyacrylamide gradient gel electrophoresis. LDL particles are subdivided according to their size into large LDL A phenotype (diameter > 25.5 nm) and small LDL B phenotype (diameter aecurrency sign25.5 nm). Renal patients with LDL A phenotype had increased oxidative stress (TOS: p lt 0.01, and TBARS: p lt 0.001) and decreased total SH- groups (p lt 0.001) compared to controls with the same LDL phenotype. A notable decrease in hemoglobin-cholesterol adduct was detected in patients with LDL A phenotype (p lt 0.001) and LDL B phenotype (p lt 0.05) compared with appropriate controls. LDL B phenotype was characterized with increased TBARS (p lt 0.05) compared with LDL A phenotype in control group. Increased oxidative stress, decreased anti-oxidative defense followed with unfavorable changes in hemoglobin-cholesterol binding capacity, could have important influence on cardiovascular disease risk in renal patients regardless of LDL phenotype. PB - Springer, Dordrecht T2 - International Urology and Nephrology T1 - Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes VL - 48 IS - 10 SP - 1683 EP - 1690 DO - 10.1007/s11255-016-1358-0 ER -
@article{ author = "Miljković, Milica and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Zeljković, Aleksandra and Vekić, Jelena and Gojković, Tamara and Bogavac-Stanojević, Nataša and Nikolić, Milan and Simić-Ogrizović, Sanja and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana", year = "2016", abstract = "Unfavorable lipid profile is a major risk factor for cardiovascular disease in renal pathology. In this study, we compared chronic renal patients and healthy controls with different LDL phenotypes (A or B) in respect of various biochemical parameters related to cardiovascular disease. Oxidative stress and anti-oxidative defense parameters [thiobarbituric acid-reacting substances (TBARS), total oxidative status (TOS), total anti-oxidative status (TAS), total protein sulfhydryl (-SH) groups], as well as red blood cell cholesterol distribution were assessed in 40 renal patients and 40 control subjects by standardized assays. LDL particle diameters were determined by polyacrylamide gradient gel electrophoresis. LDL particles are subdivided according to their size into large LDL A phenotype (diameter > 25.5 nm) and small LDL B phenotype (diameter aecurrency sign25.5 nm). Renal patients with LDL A phenotype had increased oxidative stress (TOS: p lt 0.01, and TBARS: p lt 0.001) and decreased total SH- groups (p lt 0.001) compared to controls with the same LDL phenotype. A notable decrease in hemoglobin-cholesterol adduct was detected in patients with LDL A phenotype (p lt 0.001) and LDL B phenotype (p lt 0.05) compared with appropriate controls. LDL B phenotype was characterized with increased TBARS (p lt 0.05) compared with LDL A phenotype in control group. Increased oxidative stress, decreased anti-oxidative defense followed with unfavorable changes in hemoglobin-cholesterol binding capacity, could have important influence on cardiovascular disease risk in renal patients regardless of LDL phenotype.", publisher = "Springer, Dordrecht", journal = "International Urology and Nephrology", title = "Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes", volume = "48", number = "10", pages = "1683-1690", doi = "10.1007/s11255-016-1358-0" }
Miljković, M., Kotur-Stevuljević, J., Stefanović, A., Zeljković, A., Vekić, J., Gojković, T., Bogavac-Stanojević, N., Nikolić, M., Simić-Ogrizović, S., Spasojević-Kalimanovska, V.,& Jelić-Ivanović, Z.. (2016). Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes. in International Urology and Nephrology Springer, Dordrecht., 48(10), 1683-1690. https://doi.org/10.1007/s11255-016-1358-0
Miljković M, Kotur-Stevuljević J, Stefanović A, Zeljković A, Vekić J, Gojković T, Bogavac-Stanojević N, Nikolić M, Simić-Ogrizović S, Spasojević-Kalimanovska V, Jelić-Ivanović Z. Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes. in International Urology and Nephrology. 2016;48(10):1683-1690. doi:10.1007/s11255-016-1358-0 .
Miljković, Milica, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Zeljković, Aleksandra, Vekić, Jelena, Gojković, Tamara, Bogavac-Stanojević, Nataša, Nikolić, Milan, Simić-Ogrizović, Sanja, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, "Oxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypes" in International Urology and Nephrology, 48, no. 10 (2016):1683-1690, https://doi.org/10.1007/s11255-016-1358-0 . .