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dc.creatorMiljković, Milica
dc.creatorKotur-Stevuljević, Jelena
dc.creatorStefanović, Aleksandra
dc.creatorZeljković, Aleksandra
dc.creatorVekić, Jelena
dc.creatorGojković, Tamara
dc.creatorBogavac-Stanojević, Nataša
dc.creatorNikolić, Milan
dc.creatorSimić-Ogrizović, Sanja
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorJelić-Ivanović, Zorana
dc.date.accessioned2019-09-02T11:55:27Z
dc.date.available2019-09-02T11:55:27Z
dc.date.issued2016
dc.identifier.issn0301-1623
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2724
dc.description.abstractUnfavorable lipid profile is a major risk factor for cardiovascular disease in renal pathology. In this study, we compared chronic renal patients and healthy controls with different LDL phenotypes (A or B) in respect of various biochemical parameters related to cardiovascular disease. Oxidative stress and anti-oxidative defense parameters [thiobarbituric acid-reacting substances (TBARS), total oxidative status (TOS), total anti-oxidative status (TAS), total protein sulfhydryl (-SH) groups], as well as red blood cell cholesterol distribution were assessed in 40 renal patients and 40 control subjects by standardized assays. LDL particle diameters were determined by polyacrylamide gradient gel electrophoresis. LDL particles are subdivided according to their size into large LDL A phenotype (diameter > 25.5 nm) and small LDL B phenotype (diameter aecurrency sign25.5 nm). Renal patients with LDL A phenotype had increased oxidative stress (TOS: p lt 0.01, and TBARS: p lt 0.001) and decreased total SH- groups (p lt 0.001) compared to controls with the same LDL phenotype. A notable decrease in hemoglobin-cholesterol adduct was detected in patients with LDL A phenotype (p lt 0.001) and LDL B phenotype (p lt 0.05) compared with appropriate controls. LDL B phenotype was characterized with increased TBARS (p lt 0.05) compared with LDL A phenotype in control group. Increased oxidative stress, decreased anti-oxidative defense followed with unfavorable changes in hemoglobin-cholesterol binding capacity, could have important influence on cardiovascular disease risk in renal patients regardless of LDL phenotype.en
dc.publisherSpringer, Dordrecht
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Urology and Nephrology
dc.titleOxidative stress and hemoglobin-cholesterol adduct in renal patients with different LDL phenotypesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБогавац-Станојевић, Наташа; Спасојевић-Калимановска, Весна; Николић, Милан; Векић, Јелена; Стефановић, Aлександра; Гојковић, Тамара; Зељковић, Aлександра; Котур-Стевуљевић, Јелена; Јелић-Ивановић, Зорана; Миљковић, Милица; Симић-Огризовић, Сања;
dc.citation.volume48
dc.citation.issue10
dc.citation.spage1683
dc.citation.epage1690
dc.citation.other48(10): 1683-1690
dc.citation.rankM23
dc.identifier.wos000384563100019
dc.identifier.doi10.1007/s11255-016-1358-0
dc.identifier.pmid27412679
dc.identifier.scopus2-s2.0-84978148560
dc.type.versionpublishedVersion


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