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Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents

Authorized Users Only
2016
Authors
Bekhet, Osama H.
Zeljković, Aleksandra
Vekić, Jelena
Paripović, Dušan
Janać, Jelena
Joksić, Jelena
Gojković, Tamara
Spasojević-Kalimanovska, Vesna
Peco-Antić, Amira
Miloševski-Lomić, Gordana
Jelić-Ivanović, Zorana
Article (Published version)
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Abstract
Background: Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.Methods: A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.Results: Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese c...hildren. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p= 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles ( =-0.423; p= 0.025) in the group with hypertension.Conclusions: The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity.

Source:
Scandinavian Journal of Clinical and Laboratory Investigation, 2016, 76, 6, 472-478
Publisher:
  • Taylor & Francis Ltd, Abingdon
Projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.1080/00365513.2016.1201849

ISSN: 0036-5513

PubMed: 27379467

WoS: 000384305800006

Scopus: 2-s2.0-84979080387
[ Google Scholar ]
1
1
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2727
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Bekhet, Osama H.
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Paripović, Dušan
AU  - Janać, Jelena
AU  - Joksić, Jelena
AU  - Gojković, Tamara
AU  - Spasojević-Kalimanovska, Vesna
AU  - Peco-Antić, Amira
AU  - Miloševski-Lomić, Gordana
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/2727
AB  - Background: Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.Methods: A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.Results: Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese children. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p= 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles ( =-0.423; p= 0.025) in the group with hypertension.Conclusions: The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Scandinavian Journal of Clinical and Laboratory Investigation
T1  - Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents
VL  - 76
IS  - 6
SP  - 472
EP  - 478
DO  - 10.1080/00365513.2016.1201849
ER  - 
@article{
author = "Bekhet, Osama H. and Zeljković, Aleksandra and Vekić, Jelena and Paripović, Dušan and Janać, Jelena and Joksić, Jelena and Gojković, Tamara and Spasojević-Kalimanovska, Vesna and Peco-Antić, Amira and Miloševski-Lomić, Gordana and Jelić-Ivanović, Zorana",
year = "2016",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/2727",
abstract = "Background: Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.Methods: A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.Results: Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese children. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p= 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles ( =-0.423; p= 0.025) in the group with hypertension.Conclusions: The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
title = "Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents",
volume = "76",
number = "6",
pages = "472-478",
doi = "10.1080/00365513.2016.1201849"
}
Bekhet OH, Zeljković A, Vekić J, Paripović D, Janać J, Joksić J, Gojković T, Spasojević-Kalimanovska V, Peco-Antić A, Miloševski-Lomić G, Jelić-Ivanović Z. Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents. Scandinavian Journal of Clinical and Laboratory Investigation. 2016;76(6):472-478
Bekhet, O. H., Zeljković, A., Vekić, J., Paripović, D., Janać, J., Joksić, J., Gojković, T., Spasojević-Kalimanovska, V., Peco-Antić, A., Miloševski-Lomić, G.,& Jelić-Ivanović, Z. (2016). Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents.
Scandinavian Journal of Clinical and Laboratory InvestigationTaylor & Francis Ltd, Abingdon., 76(6), 472-478.
https://doi.org/10.1080/00365513.2016.1201849
Bekhet Osama H., Zeljković Aleksandra, Vekić Jelena, Paripović Dušan, Janać Jelena, Joksić Jelena, Gojković Tamara, Spasojević-Kalimanovska Vesna, Peco-Antić Amira, Miloševski-Lomić Gordana, Jelić-Ivanović Zorana, "Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents" 76, no. 6 (2016):472-478,
https://doi.org/10.1080/00365513.2016.1201849 .

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