Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents
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2016
Authors
Bekhet, Osama H.Zeljković, Aleksandra

Vekić, Jelena

Paripović, Dušan

Janać, Jelena

Joksić, Jelena
Gojković, Tamara

Spasojević-Kalimanovska, Vesna

Peco-Antić, Amira
Miloševski-Lomić, Gordana
Jelić-Ivanović, Zorana

Article (Published version)

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Background: Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.Methods: A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.Results: Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese c...hildren. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p= 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles ( =-0.423; p= 0.025) in the group with hypertension.Conclusions: The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity.
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Scandinavian Journal of Clinical and Laboratory Investigation, 2016, 76, 6, 472-478Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
DOI: 10.1080/00365513.2016.1201849
ISSN: 0036-5513
PubMed: 27379467
WoS: 000384305800006
Scopus: 2-s2.0-84979080387
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PharmacyTY - JOUR AU - Bekhet, Osama H. AU - Zeljković, Aleksandra AU - Vekić, Jelena AU - Paripović, Dušan AU - Janać, Jelena AU - Joksić, Jelena AU - Gojković, Tamara AU - Spasojević-Kalimanovska, Vesna AU - Peco-Antić, Amira AU - Miloševski-Lomić, Gordana AU - Jelić-Ivanović, Zorana PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2727 AB - Background: Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.Methods: A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.Results: Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese children. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p= 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles ( =-0.423; p= 0.025) in the group with hypertension.Conclusions: The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity. PB - Taylor & Francis Ltd, Abingdon T2 - Scandinavian Journal of Clinical and Laboratory Investigation T1 - Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents VL - 76 IS - 6 SP - 472 EP - 478 DO - 10.1080/00365513.2016.1201849 ER -
@article{ author = "Bekhet, Osama H. and Zeljković, Aleksandra and Vekić, Jelena and Paripović, Dušan and Janać, Jelena and Joksić, Jelena and Gojković, Tamara and Spasojević-Kalimanovska, Vesna and Peco-Antić, Amira and Miloševski-Lomić, Gordana and Jelić-Ivanović, Zorana", year = "2016", abstract = "Background: Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.Methods: A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.Results: Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese children. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p= 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles ( =-0.423; p= 0.025) in the group with hypertension.Conclusions: The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Scandinavian Journal of Clinical and Laboratory Investigation", title = "Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents", volume = "76", number = "6", pages = "472-478", doi = "10.1080/00365513.2016.1201849" }
Bekhet, O. H., Zeljković, A., Vekić, J., Paripović, D., Janać, J., Joksić, J., Gojković, T., Spasojević-Kalimanovska, V., Peco-Antić, A., Miloševski-Lomić, G.,& Jelić-Ivanović, Z.. (2016). Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation Taylor & Francis Ltd, Abingdon., 76(6), 472-478. https://doi.org/10.1080/00365513.2016.1201849
Bekhet OH, Zeljković A, Vekić J, Paripović D, Janać J, Joksić J, Gojković T, Spasojević-Kalimanovska V, Peco-Antić A, Miloševski-Lomić G, Jelić-Ivanović Z. Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation. 2016;76(6):472-478. doi:10.1080/00365513.2016.1201849 .
Bekhet, Osama H., Zeljković, Aleksandra, Vekić, Jelena, Paripović, Dušan, Janać, Jelena, Joksić, Jelena, Gojković, Tamara, Spasojević-Kalimanovska, Vesna, Peco-Antić, Amira, Miloševski-Lomić, Gordana, Jelić-Ivanović, Zorana, "Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents" in Scandinavian Journal of Clinical and Laboratory Investigation, 76, no. 6 (2016):472-478, https://doi.org/10.1080/00365513.2016.1201849 . .