Show simple item record

dc.creatorBekhet, Osama H.
dc.creatorZeljković, Aleksandra
dc.creatorVekić, Jelena
dc.creatorParipović, Dušan
dc.creatorJanać, Jelena
dc.creatorJoksić, Jelena
dc.creatorGojković, Tamara
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorPeco-Antić, Amira
dc.creatorMiloševski-Lomić, Gordana
dc.creatorJelić-Ivanović, Zorana
dc.date.accessioned2019-09-02T11:55:29Z
dc.date.available2019-09-02T11:55:29Z
dc.date.issued2016
dc.identifier.issn0036-5513
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2727
dc.description.abstractBackground: Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.Methods: A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.Results: Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese children. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p= 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles ( =-0.423; p= 0.025) in the group with hypertension.Conclusions: The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourceScandinavian Journal of Clinical and Laboratory Investigation
dc.titleHypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescentsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПецо-Aнтић, Aмира; Јелић-Ивановић, Зорана; Париповић, Душан; Јанац, Јелена; Зељковић, Aлександра; Бекхет, Осама Х.; Векић, Јелена; Спасојевић-Калимановска, Весна; Гојковић, Тамара; Милошевски-Ломић, Гордана; Јоксић, Јелена;
dc.citation.volume76
dc.citation.issue6
dc.citation.spage472
dc.citation.epage478
dc.citation.other76(6): 472-478
dc.citation.rankM23
dc.identifier.wos000384305800006
dc.identifier.doi10.1080/00365513.2016.1201849
dc.identifier.pmid27379467
dc.identifier.scopus2-s2.0-84979080387
dc.identifier.rcubconv_3667
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record