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Proinflammatory proteins in female and male patients with primary antiphospholipid syndrome: preliminary data

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2016
Authors
Becarević, Mirjana
Ignjatović, Svetlana
Article (Published version)
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Abstract
The latest classification criteria for the diagnosis of the antiphospholipid syndrome (APS, an autoimmune disease characterized by thromboses, miscarriages and presence of antiphospholipid antibodies (Abs)) emphasized that thrombotic manifestations of APS should be without any signs of an inflammatory process. However, atherosclerosis (a chronic inflammatory response to the accumulation of lipoproteins in the walls of arteries) and APS are characterized by some similar features. We evaluated whether proinflammatory proteins were associated with the features of the primary APS (PAPS). PAPS patients without obstetric complications and with impaired lipid profile were included in the study. Antiphospholipid antibodies, TNF-alpha, and apo(a) were determined by ELISA. Complement components and hsCRP were measured by immunonephelometry. Decreased C3c was observed in female patients with increased titers of IgG anti-beta 2gpI (chi(2) = 3.939, P = 0.047) and in male patients with increased IgM... anticardiolipin Abs (chi(2) = 4.286, P = 0.038). Pulmonary emboli were associated with interleukin (IL)-6 in male (chi(2) = 6.519, P = 0.011) and in female (chi(2) = 10.405, P = 0.001) patients. Cerebrovascular insults were associated with LDL-cholesterol (P = 0.05, 95 % CI: 1.003 - 12.739) in female and with apo(a) (P = 0.016, 95 % CI: 0.000-0.003) in male patients. Older female patients had increased LDL-cholesterol levels and frequency of myocardial infarctions. Proinflammatory proteins were associated with features of primary APS. No real gender differences in regard to proinflammatory protein levels were observed. Premenopausal state of female PAPS patients confers lower cardiovascular risk.

Source:
Clinical Rheumatology, 2016, 35, 10, 2477-2483
Publisher:
  • Springer London Ltd, London
Funding / projects:
  • Biomarkers of organ damage and dysfunction (RS-175036)

DOI: 10.1007/s10067-016-3345-3

ISSN: 0770-3198

PubMed: 27370963

WoS: 000385142900013

Scopus: 2-s2.0-84976481694
[ Google Scholar ]
11
9
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2733
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  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Becarević, Mirjana
AU  - Ignjatović, Svetlana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2733
AB  - The latest classification criteria for the diagnosis of the antiphospholipid syndrome (APS, an autoimmune disease characterized by thromboses, miscarriages and presence of antiphospholipid antibodies (Abs)) emphasized that thrombotic manifestations of APS should be without any signs of an inflammatory process. However, atherosclerosis (a chronic inflammatory response to the accumulation of lipoproteins in the walls of arteries) and APS are characterized by some similar features. We evaluated whether proinflammatory proteins were associated with the features of the primary APS (PAPS). PAPS patients without obstetric complications and with impaired lipid profile were included in the study. Antiphospholipid antibodies, TNF-alpha, and apo(a) were determined by ELISA. Complement components and hsCRP were measured by immunonephelometry. Decreased C3c was observed in female patients with increased titers of IgG anti-beta 2gpI (chi(2) = 3.939, P = 0.047) and in male patients with increased IgM anticardiolipin Abs (chi(2) = 4.286, P = 0.038). Pulmonary emboli were associated with interleukin (IL)-6 in male (chi(2) = 6.519, P = 0.011) and in female (chi(2) = 10.405, P = 0.001) patients. Cerebrovascular insults were associated with LDL-cholesterol (P = 0.05, 95 % CI: 1.003 - 12.739) in female and with apo(a) (P = 0.016, 95 % CI: 0.000-0.003) in male patients. Older female patients had increased LDL-cholesterol levels and frequency of myocardial infarctions. Proinflammatory proteins were associated with features of primary APS. No real gender differences in regard to proinflammatory protein levels were observed. Premenopausal state of female PAPS patients confers lower cardiovascular risk.
PB  - Springer London Ltd, London
T2  - Clinical Rheumatology
T1  - Proinflammatory proteins in female and male patients with primary antiphospholipid syndrome: preliminary data
VL  - 35
IS  - 10
SP  - 2477
EP  - 2483
DO  - 10.1007/s10067-016-3345-3
ER  - 
@article{
author = "Becarević, Mirjana and Ignjatović, Svetlana",
year = "2016",
abstract = "The latest classification criteria for the diagnosis of the antiphospholipid syndrome (APS, an autoimmune disease characterized by thromboses, miscarriages and presence of antiphospholipid antibodies (Abs)) emphasized that thrombotic manifestations of APS should be without any signs of an inflammatory process. However, atherosclerosis (a chronic inflammatory response to the accumulation of lipoproteins in the walls of arteries) and APS are characterized by some similar features. We evaluated whether proinflammatory proteins were associated with the features of the primary APS (PAPS). PAPS patients without obstetric complications and with impaired lipid profile were included in the study. Antiphospholipid antibodies, TNF-alpha, and apo(a) were determined by ELISA. Complement components and hsCRP were measured by immunonephelometry. Decreased C3c was observed in female patients with increased titers of IgG anti-beta 2gpI (chi(2) = 3.939, P = 0.047) and in male patients with increased IgM anticardiolipin Abs (chi(2) = 4.286, P = 0.038). Pulmonary emboli were associated with interleukin (IL)-6 in male (chi(2) = 6.519, P = 0.011) and in female (chi(2) = 10.405, P = 0.001) patients. Cerebrovascular insults were associated with LDL-cholesterol (P = 0.05, 95 % CI: 1.003 - 12.739) in female and with apo(a) (P = 0.016, 95 % CI: 0.000-0.003) in male patients. Older female patients had increased LDL-cholesterol levels and frequency of myocardial infarctions. Proinflammatory proteins were associated with features of primary APS. No real gender differences in regard to proinflammatory protein levels were observed. Premenopausal state of female PAPS patients confers lower cardiovascular risk.",
publisher = "Springer London Ltd, London",
journal = "Clinical Rheumatology",
title = "Proinflammatory proteins in female and male patients with primary antiphospholipid syndrome: preliminary data",
volume = "35",
number = "10",
pages = "2477-2483",
doi = "10.1007/s10067-016-3345-3"
}
Becarević, M.,& Ignjatović, S.. (2016). Proinflammatory proteins in female and male patients with primary antiphospholipid syndrome: preliminary data. in Clinical Rheumatology
Springer London Ltd, London., 35(10), 2477-2483.
https://doi.org/10.1007/s10067-016-3345-3
Becarević M, Ignjatović S. Proinflammatory proteins in female and male patients with primary antiphospholipid syndrome: preliminary data. in Clinical Rheumatology. 2016;35(10):2477-2483.
doi:10.1007/s10067-016-3345-3 .
Becarević, Mirjana, Ignjatović, Svetlana, "Proinflammatory proteins in female and male patients with primary antiphospholipid syndrome: preliminary data" in Clinical Rheumatology, 35, no. 10 (2016):2477-2483,
https://doi.org/10.1007/s10067-016-3345-3 . .

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