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dc.creatorBecarević, Mirjana
dc.creatorIgnjatović, Svetlana
dc.date.accessioned2019-09-02T11:55:40Z
dc.date.available2019-09-02T11:55:40Z
dc.date.issued2016
dc.identifier.issn0770-3198
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2733
dc.description.abstractThe latest classification criteria for the diagnosis of the antiphospholipid syndrome (APS, an autoimmune disease characterized by thromboses, miscarriages and presence of antiphospholipid antibodies (Abs)) emphasized that thrombotic manifestations of APS should be without any signs of an inflammatory process. However, atherosclerosis (a chronic inflammatory response to the accumulation of lipoproteins in the walls of arteries) and APS are characterized by some similar features. We evaluated whether proinflammatory proteins were associated with the features of the primary APS (PAPS). PAPS patients without obstetric complications and with impaired lipid profile were included in the study. Antiphospholipid antibodies, TNF-alpha, and apo(a) were determined by ELISA. Complement components and hsCRP were measured by immunonephelometry. Decreased C3c was observed in female patients with increased titers of IgG anti-beta 2gpI (chi(2) = 3.939, P = 0.047) and in male patients with increased IgM anticardiolipin Abs (chi(2) = 4.286, P = 0.038). Pulmonary emboli were associated with interleukin (IL)-6 in male (chi(2) = 6.519, P = 0.011) and in female (chi(2) = 10.405, P = 0.001) patients. Cerebrovascular insults were associated with LDL-cholesterol (P = 0.05, 95 % CI: 1.003 - 12.739) in female and with apo(a) (P = 0.016, 95 % CI: 0.000-0.003) in male patients. Older female patients had increased LDL-cholesterol levels and frequency of myocardial infarctions. Proinflammatory proteins were associated with features of primary APS. No real gender differences in regard to proinflammatory protein levels were observed. Premenopausal state of female PAPS patients confers lower cardiovascular risk.en
dc.publisherSpringer London Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Rheumatology
dc.titleProinflammatory proteins in female and male patients with primary antiphospholipid syndrome: preliminary dataen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractИгњатовић, Светлана; Бецаревић, Мирјана;
dc.citation.volume35
dc.citation.issue10
dc.citation.spage2477
dc.citation.epage2483
dc.citation.other35(10): 2477-2483
dc.citation.rankM23
dc.identifier.wos000385142900013
dc.identifier.doi10.1007/s10067-016-3345-3
dc.identifier.pmid27370963
dc.identifier.scopus2-s2.0-84976481694
dc.identifier.rcubconv_3678
dc.type.versionpublishedVersion


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