Приказ основних података о документу

dc.creatorPopević, Spasoje
dc.creatorŠumarac, Zorica
dc.creatorJovanović, Dragana
dc.creatorBabić, Dragan
dc.creatorStjepanović, Mihailo
dc.creatorJovičić, Snežana
dc.creatorSobić-Saranović, Dragana
dc.creatorFilipović, Snežana
dc.creatorGvozdenović, Branko
dc.creatorOmcikus, Maja
dc.creatorMilovanović, Andela
dc.creatorVidenović-Ivanov, Jelica
dc.creatorRadović, Ana
dc.creatorZugić, Vladimir
dc.creatorVučinić-Mihailović, Violeta
dc.date.accessioned2019-09-02T11:56:09Z
dc.date.available2019-09-02T11:56:09Z
dc.date.issued2016
dc.identifier.issn1452-8258
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2749
dc.description.abstractBackground: Until now, a proper biomarker(s) to evaluate sarcoidosis activity has not been recognized. The aims of this study were to evaluate the sensitivity and specificity of the two biomarkers of sarcoidosis activity already in use (serum angiotensin converting enzyme - ACE and serum chitotriosidase) in a population of 430 sarcoidosis patients. The activities of these markers were also analyzed in a group of 264 healthy controls. Methods: Four hundred and thirty biopsy positive sarcoidosis patients were divided into groups with active and inactive disease, and groups with acute or chronic disease. In a subgroup of 55 sarcoidosis patients, activity was also assessed by F-18 fluorodeoxyglucose positron emission tomography (F-18-FDG-PET) scanning. Both serum chitotriosidase and ACE levels showed non-normal distribution, so nonparametric tests were used in statistical analysis. Results: Serum chitotriosidase activities were almost 6 times higher in patients with active sarcoidosis than in healthy controls and inactive disease. A serum chitotriosidase value of 100 nmol/mL/h had the sensitivity of 82.5% and specificity of 70.0%. A serum ACE activity cutoff value of 32.0 U/L had the sensitivity of 66.0% and the specificity of 54%. A statistically significant correlation was obtained between the focal granulomatous activity detected on F-18-FDG PET/CT and serum chitotriosidase levels, but no such correlation was found with ACE. The levels of serum chitotriosidase activity significantly correlated with the disease duration (P lt 0.0001). Also, serum chitotriosidase significantly correlated with clinical outcome status (COS) categories (rho=0.272, P=0.001). Conclusions: Serum chitotriosidase proved to be a reliable biomarker of sarcoidosis activity and disease chronicity.en
dc.publisherDruštvo medicinskih biohemičara Srbije, Beograd i Versita
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175018/RS//
dc.rightsopenAccess
dc.sourceJournal of Medical Biochemistry
dc.titleVerifying Sarcoidosis Activity: Chitotriosidase Versus ACE in Sarcoidosis - A Case-Control Studyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈовичић, Снежана; Радовић, Aна; Зугић, Владимир; Вучинић-Михаиловић, Виолета; Попевић, Спасоје; Виденовић-Иванов, Јелица; Шумарац, Зорица; Јовановић, Драгана; Бабић, Драган; Стјепановић, Михаило; Собић-Сарановић, Драгана; Филиповић, Снежана; Гвозденовић, Бранко; Омцикус, Маја; Миловановић, Aндела;
dc.citation.volume35
dc.citation.issue4
dc.citation.spage390
dc.citation.epage400
dc.citation.other35(4): 390-400
dc.citation.rankM23
dc.identifier.wos000386412400003
dc.identifier.doi10.1515/jomb-2016-0017
dc.identifier.pmid28670191
dc.identifier.scopus2-s2.0-84994908481
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs//bitstream/id/1393/2747.pdf
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу