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dc.creatorSopić, Miron
dc.creatorJoksić, Jelena
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorBogavac-Stanojević, Nataša
dc.creatorSimić-Ogrizović, Sanja
dc.creatorKravljaca, Milica
dc.creatorJelić-Ivanović, Zorana
dc.date.accessioned2019-09-02T11:56:10Z
dc.date.available2019-09-02T11:56:10Z
dc.date.issued2016
dc.identifier.issn1452-8258
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2750
dc.description.abstractBackground: Since the rise in plasma adiponectin levels in chronic kidney disease (CKD) patients has not yet been elucidated, we sought to investigate if patients on hemodialysis (HD) have altered expression of adiponectin receptors in peripheral blood mononuclear cells (PBMCs) compared to healthy subjects. Methods: This study included 31 patients with chronic kidney disease on HD and 33 healthy subjects (CG). Circulating adiponectin levels were measured by ELISA while AdipoR1 and AdipoR2 mRNA levels in PBMCs were determined by real-time PCR. Results: Plasma adiponectin levels were significantly higher in patients compared to control group (P=0.036). After adjustment for age, BMI and creatinine, this difference became even more significant (P=0.004). In both groups adiponectin correlated with creatinine (CG: r=-0.472, P=0.006; HD: r=-0.375, P=0.038), triglycerides (CG: r=0.490, P=0.004; HD: r=-0.488, P=0.005), insulin (CG: r=-0.386, P=0.038; HD: r=-0.506, P=0.012) and high density lipoprotein cholesterol (HDL-C) (CG: r=-0.672, P lt 0.001; HD: r=-0.584, P=0.001). Significantly lower expression of PBMCs AdipoR1 mRNA was found in patients compared to CG (P=0.034), while AdipoR2 mRNA levels were similarly expressed in PBMCs in both groups. Conclusions: Complex pathological processes in CKD cause downregulation of AdipoR1 which could ultimately influence AdipoR1 protein levels leading to a state of adiponectin resistance.en
dc.publisherDruštvo medicinskih biohemičara Srbije, Beograd i Versita
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceJournal of Medical Biochemistry
dc.titleDownregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈелић-Ивановић, Зорана; Спасојевић-Калимановска, Весна; Јоксић, Јелена; Богавац-Станојевић, Наташа; Симић-Огризовић, Сања; Сопић, Мирон; Крављаца, Милица;
dc.citation.volume35
dc.citation.issue4
dc.citation.spage436
dc.citation.epage442
dc.citation.other35(4): 436-442
dc.citation.rankM23
dc.identifier.wos000386412400008
dc.identifier.doi10.1515/jomb-2016-0007
dc.identifier.pmid28670196
dc.identifier.scopus2-s2.0-84994810293
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1394/2748.pdf
dc.identifier.rcubconv_3689
dc.type.versionpublishedVersion


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