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dc.creatorMichalickova, Danica
dc.creatorMinić, Rajna
dc.creatorDikić, Nenad
dc.creatorAnđelković, Marija
dc.creatorKostić-Vučićević, Marija
dc.creatorStojmenović, Tamara
dc.creatorNikolić, Ivan
dc.creatorĐorđević, Brižita
dc.date.accessioned2019-09-02T11:56:18Z
dc.date.available2019-09-02T11:56:18Z
dc.date.issued2016
dc.identifier.issn1715-5312
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2753
dc.description.abstractA randomized, double-blind, placebo-controlled study was conducted to evaluate if Lactobacillus helveticus Lafti L10 (Lallemand Health Solutions, Montreal, Que., Canada) supplementation during 14 weeks in winter can influence the duration, severity, and incidence of upper respiratory tract illness (URTI), as well as to monitor different immune parameters in the population of elite athletes. Before and after the treatment, cardiopulmonary testing and self-rated state of moods evaluation (by Profile of Mood States questionnaire) were performed and blood samples were collected. Thirty-nine elite athletes were randomized either to the placebo (n = 19) or the probiotic (n = 20) group. The probiotic group received L. helveticus Lafti L10, 2 x 10(10) Colony Forming Units. Lafti L10 significantly shortened the URTI episode duration (7.25 +/- 2.90 vs. 10.64 +/- 4.67 days, p = 0.047) and decreased the number of symptoms in the probiotic group (4.92 +/- 1.96 vs. 6.91 +/- 1.22, p = 0.035). Severity and incidence of URTI did not differ between the treatments. There were no significant changes in leukocyte subpopulation abundance, transforming growth factor-beta serum levels, level of interleukin-10 secreted from peptidoglican stimulated peripheral blood mononuclear cells (PBMCs), interferon-gamma level secreted from concanavalin A-stimulated PBMCs or viability/proliferation of PBMCs upon antigen stimulation. Group effect for CD4+/CD8+ ratio was significant (F-[1,F-37] = 6.99, p = 0.020, eta(2) = 0.350); this difference was not significant at baseline, but was evident after 14 weeks (p = 0.02). A significant interaction effect was noted for self-rated sense of vigor (F-[1,F-37] = 11.76, p = 0.009, eta(2) = 0.595). Self-rated sense of vigor increased in the probiotic group (18.5 +/- 4.1 vs. 21.0 +/- 2.6, p = 0.012). Probiotic strain Lafti L10 can be a beneficial nutritional supplement for the reduction of URTI length in elite athletes.en
dc.publisherCanadian Science Publishing, Nrc Research Press, Ottawa
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.rightsrestrictedAccess
dc.sourceApplied Physiology Nutrition and Metabolism
dc.titleLactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trialen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractКостић-Вучићевић, Марија; Дикић, Ненад; Стојменовић, Тамара; Минић, Рајна; Aнђелковић, Марија; Мицхалицкова, Даница; Ђорђевић, Брижита; Николић, Иван;
dc.citation.volume41
dc.citation.issue7
dc.citation.spage782
dc.citation.epage789
dc.citation.other41(7): 782-789
dc.citation.rankM22
dc.description.otherPeer-reviewed manuscript: [http://farfar.pharmacy.bg.ac.rs/handle/123456789/3441]
dc.identifier.wos000379430100013
dc.identifier.doi10.1139/apnm-2015-0541
dc.identifier.pmid27363733
dc.identifier.scopus2-s2.0-84977579626
dc.identifier.rcubconv_3613
dc.type.versionpublishedVersion


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