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High Interleukin 27 Production is Associated with Early Clinical Stage and Localized Disease in Patients with Melanoma

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2016
2752.pdf (255.3Kb)
Authors
Bisevac, Jelena Pantic
Stanojević, Ivan
Mijušković, Željko
Banović, Tatjana
Đukić, Mirjana
Vojvodić, Danilo
Article (Published version)
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Abstract
Background: The immune response in patients with melanoma is an important focus of research due to the tumor's resistance and immunotherapy possibilities. IL-27 is one of the cytokines with antitumor properties. The role of IL-27 in the pathogenesis of melanoma is still unclear. The aim of this study was to examine the association between serum IL-27 levels and the clinical parameters of melanoma patients. Methods: The IL-27 concentration was determined by commercial ELISA in serum samples from melanoma patients (n=72) and healthy control subjects (n=44). Patients were classified according to AJCC clinical stage, TNM stage, the length of progression-free interval (PFI) and the extent of the disease (localized or widespread). Results: Average IL-27 values were increased in patients with early stages of melanoma compared to patients with terminal stages and control values. The highest IL-27 concentration was found in stage Ila. Patients in stages III and IV had significantly lower values... of IL-27 compared to control. Patients with localized melanoma and shorter PFI had insignificantly increased IL-27 levels compared to patients with widespread disease and longer PFI. Patients with metastatic disease and stage TNM4 had significantly lower average IL-27 values compared to control. Patients with high production of IL-27 (>1000 pg/mL) were most numerous in Ila AJCC stage, with initial tumor size TNM2 and in the group of patients with localized disease. Conclusions: High levels of IL-27 in patients with melanoma are associated with the initial stages and localized disease.

Source:
Journal of Medical Biochemistry, 2016, 35, 4, 443-450
Publisher:
  • Društvo medicinskih biohemičara Srbije, Beograd i Versita

DOI: 10.1515/jomb-2016-0018

ISSN: 1452-8258

PubMed: 28670197

WoS: 000386412400009

Scopus: 2-s2.0-84994879762
[ Google Scholar ]
6
5
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2754
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Bisevac, Jelena Pantic
AU  - Stanojević, Ivan
AU  - Mijušković, Željko
AU  - Banović, Tatjana
AU  - Đukić, Mirjana
AU  - Vojvodić, Danilo
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2754
AB  - Background: The immune response in patients with melanoma is an important focus of research due to the tumor's resistance and immunotherapy possibilities. IL-27 is one of the cytokines with antitumor properties. The role of IL-27 in the pathogenesis of melanoma is still unclear. The aim of this study was to examine the association between serum IL-27 levels and the clinical parameters of melanoma patients. Methods: The IL-27 concentration was determined by commercial ELISA in serum samples from melanoma patients (n=72) and healthy control subjects (n=44). Patients were classified according to AJCC clinical stage, TNM stage, the length of progression-free interval (PFI) and the extent of the disease (localized or widespread). Results: Average IL-27 values were increased in patients with early stages of melanoma compared to patients with terminal stages and control values. The highest IL-27 concentration was found in stage Ila. Patients in stages III and IV had significantly lower values of IL-27 compared to control. Patients with localized melanoma and shorter PFI had insignificantly increased IL-27 levels compared to patients with widespread disease and longer PFI. Patients with metastatic disease and stage TNM4 had significantly lower average IL-27 values compared to control. Patients with high production of IL-27 (>1000 pg/mL) were most numerous in Ila AJCC stage, with initial tumor size TNM2 and in the group of patients with localized disease. Conclusions: High levels of IL-27 in patients with melanoma are associated with the initial stages and localized disease.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - High Interleukin 27 Production is Associated with Early Clinical Stage and Localized Disease in Patients with Melanoma
VL  - 35
IS  - 4
SP  - 443
EP  - 450
DO  - 10.1515/jomb-2016-0018
ER  - 
@article{
author = "Bisevac, Jelena Pantic and Stanojević, Ivan and Mijušković, Željko and Banović, Tatjana and Đukić, Mirjana and Vojvodić, Danilo",
year = "2016",
abstract = "Background: The immune response in patients with melanoma is an important focus of research due to the tumor's resistance and immunotherapy possibilities. IL-27 is one of the cytokines with antitumor properties. The role of IL-27 in the pathogenesis of melanoma is still unclear. The aim of this study was to examine the association between serum IL-27 levels and the clinical parameters of melanoma patients. Methods: The IL-27 concentration was determined by commercial ELISA in serum samples from melanoma patients (n=72) and healthy control subjects (n=44). Patients were classified according to AJCC clinical stage, TNM stage, the length of progression-free interval (PFI) and the extent of the disease (localized or widespread). Results: Average IL-27 values were increased in patients with early stages of melanoma compared to patients with terminal stages and control values. The highest IL-27 concentration was found in stage Ila. Patients in stages III and IV had significantly lower values of IL-27 compared to control. Patients with localized melanoma and shorter PFI had insignificantly increased IL-27 levels compared to patients with widespread disease and longer PFI. Patients with metastatic disease and stage TNM4 had significantly lower average IL-27 values compared to control. Patients with high production of IL-27 (>1000 pg/mL) were most numerous in Ila AJCC stage, with initial tumor size TNM2 and in the group of patients with localized disease. Conclusions: High levels of IL-27 in patients with melanoma are associated with the initial stages and localized disease.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "High Interleukin 27 Production is Associated with Early Clinical Stage and Localized Disease in Patients with Melanoma",
volume = "35",
number = "4",
pages = "443-450",
doi = "10.1515/jomb-2016-0018"
}
Bisevac, J. P., Stanojević, I., Mijušković, Ž., Banović, T., Đukić, M.,& Vojvodić, D.. (2016). High Interleukin 27 Production is Associated with Early Clinical Stage and Localized Disease in Patients with Melanoma. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 35(4), 443-450.
https://doi.org/10.1515/jomb-2016-0018
Bisevac JP, Stanojević I, Mijušković Ž, Banović T, Đukić M, Vojvodić D. High Interleukin 27 Production is Associated with Early Clinical Stage and Localized Disease in Patients with Melanoma. in Journal of Medical Biochemistry. 2016;35(4):443-450.
doi:10.1515/jomb-2016-0018 .
Bisevac, Jelena Pantic, Stanojević, Ivan, Mijušković, Željko, Banović, Tatjana, Đukić, Mirjana, Vojvodić, Danilo, "High Interleukin 27 Production is Associated with Early Clinical Stage and Localized Disease in Patients with Melanoma" in Journal of Medical Biochemistry, 35, no. 4 (2016):443-450,
https://doi.org/10.1515/jomb-2016-0018 . .

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