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dc.creatorBisevac, Jelena Pantic
dc.creatorStanojević, Ivan
dc.creatorMijušković, Željko
dc.creatorBanović, Tatjana
dc.creatorĐukić, Mirjana
dc.creatorVojvodić, Danilo
dc.date.accessioned2019-09-02T11:56:19Z
dc.date.available2019-09-02T11:56:19Z
dc.date.issued2016
dc.identifier.issn1452-8258
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2754
dc.description.abstractBackground: The immune response in patients with melanoma is an important focus of research due to the tumor's resistance and immunotherapy possibilities. IL-27 is one of the cytokines with antitumor properties. The role of IL-27 in the pathogenesis of melanoma is still unclear. The aim of this study was to examine the association between serum IL-27 levels and the clinical parameters of melanoma patients. Methods: The IL-27 concentration was determined by commercial ELISA in serum samples from melanoma patients (n=72) and healthy control subjects (n=44). Patients were classified according to AJCC clinical stage, TNM stage, the length of progression-free interval (PFI) and the extent of the disease (localized or widespread). Results: Average IL-27 values were increased in patients with early stages of melanoma compared to patients with terminal stages and control values. The highest IL-27 concentration was found in stage Ila. Patients in stages III and IV had significantly lower values of IL-27 compared to control. Patients with localized melanoma and shorter PFI had insignificantly increased IL-27 levels compared to patients with widespread disease and longer PFI. Patients with metastatic disease and stage TNM4 had significantly lower average IL-27 values compared to control. Patients with high production of IL-27 (>1000 pg/mL) were most numerous in Ila AJCC stage, with initial tumor size TNM2 and in the group of patients with localized disease. Conclusions: High levels of IL-27 in patients with melanoma are associated with the initial stages and localized disease.en
dc.publisherDruštvo medicinskih biohemičara Srbije, Beograd i Versita
dc.rightsopenAccess
dc.sourceJournal of Medical Biochemistry
dc.titleHigh Interleukin 27 Production is Associated with Early Clinical Stage and Localized Disease in Patients with Melanomaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтанојевић, Иван; Бисевац, Јелена Пантиц; Бановић, Татјана; Мијушковић, Жељко; Ђукић, Мирјана; Војводић, Данило;
dc.citation.volume35
dc.citation.issue4
dc.citation.spage443
dc.citation.epage450
dc.citation.other35(4): 443-450
dc.citation.rankM23
dc.identifier.wos000386412400009
dc.identifier.doi10.1515/jomb-2016-0018
dc.identifier.pmid28670197
dc.identifier.scopus2-s2.0-84994879762
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1398/2752.pdf
dc.identifier.rcubconv_3690
dc.type.versionpublishedVersion


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