Приказ основних података о документу
High Interleukin 27 Production is Associated with Early Clinical Stage and Localized Disease in Patients with Melanoma
dc.creator | Bisevac, Jelena Pantic | |
dc.creator | Stanojević, Ivan | |
dc.creator | Mijušković, Željko | |
dc.creator | Banović, Tatjana | |
dc.creator | Đukić, Mirjana | |
dc.creator | Vojvodić, Danilo | |
dc.date.accessioned | 2019-09-02T11:56:19Z | |
dc.date.available | 2019-09-02T11:56:19Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1452-8258 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2754 | |
dc.description.abstract | Background: The immune response in patients with melanoma is an important focus of research due to the tumor's resistance and immunotherapy possibilities. IL-27 is one of the cytokines with antitumor properties. The role of IL-27 in the pathogenesis of melanoma is still unclear. The aim of this study was to examine the association between serum IL-27 levels and the clinical parameters of melanoma patients. Methods: The IL-27 concentration was determined by commercial ELISA in serum samples from melanoma patients (n=72) and healthy control subjects (n=44). Patients were classified according to AJCC clinical stage, TNM stage, the length of progression-free interval (PFI) and the extent of the disease (localized or widespread). Results: Average IL-27 values were increased in patients with early stages of melanoma compared to patients with terminal stages and control values. The highest IL-27 concentration was found in stage Ila. Patients in stages III and IV had significantly lower values of IL-27 compared to control. Patients with localized melanoma and shorter PFI had insignificantly increased IL-27 levels compared to patients with widespread disease and longer PFI. Patients with metastatic disease and stage TNM4 had significantly lower average IL-27 values compared to control. Patients with high production of IL-27 (>1000 pg/mL) were most numerous in Ila AJCC stage, with initial tumor size TNM2 and in the group of patients with localized disease. Conclusions: High levels of IL-27 in patients with melanoma are associated with the initial stages and localized disease. | en |
dc.publisher | Društvo medicinskih biohemičara Srbije, Beograd i Versita | |
dc.rights | openAccess | |
dc.source | Journal of Medical Biochemistry | |
dc.title | High Interleukin 27 Production is Associated with Early Clinical Stage and Localized Disease in Patients with Melanoma | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Станојевић, Иван; Бисевац, Јелена Пантиц; Бановић, Татјана; Мијушковић, Жељко; Ђукић, Мирјана; Војводић, Данило; | |
dc.citation.volume | 35 | |
dc.citation.issue | 4 | |
dc.citation.spage | 443 | |
dc.citation.epage | 450 | |
dc.citation.other | 35(4): 443-450 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000386412400009 | |
dc.identifier.doi | 10.1515/jomb-2016-0018 | |
dc.identifier.pmid | 28670197 | |
dc.identifier.scopus | 2-s2.0-84994879762 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1398/2752.pdf | |
dc.type.version | publishedVersion |