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dc.creatorKolundžić, Marina
dc.creatorGroznanić, Nađa
dc.creatorStanojković, Tatjana
dc.creatorMilenković, Marina
dc.creatorDinić, Miroslav
dc.creatorGolić, Nataša
dc.creatorKojić, Milan
dc.creatorKundaković, Tatjana
dc.date.accessioned2019-09-02T11:56:19Z
dc.date.available2019-09-02T11:56:19Z
dc.date.issued2016
dc.identifier.issn1521-9437
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2755
dc.description.abstractCyclohexane, dichloromethane, and methanol extracts of the medicinal mushroom Laetiporus sulphureus were tested for their antimicrobial, cytotoxic, and radical scavenging activities. Total polyphenol content was also determined. Regarding the amount of the phenolic compounds in the methanol extract, there were 14.1 +/- 0.6 mg gallic acid/g dry extract and a concentration of 0.66 +/- 0.15 mg/mL resulted in the removal of 50% of the DPPH radicals (half-maximal inhibitory concentration [IC50]) . The average minimum inhibitory concentrations (MICs) against a select panel of microorganisms were between 125 and 250 mu g/mL, and the methanolic extract significantly inhibited the growth of Staphylococcus aureus (MIC, 31.25 mu g/mL). Also, cyclohexane and dichloromethane extracts inhibited the growth of Helicobacter pylori (MIC, 62.5 mu g/mL). Cyclohexane and dichloromethane extracts showed higher antiproliferative action compared with the methanol extract. The lowest IC50 was induced on HeLa cells by dichloromethane extract (IC50,67.20 +/- 5.49 mu g/mL), followed by cyclohexane extract (IC50 75.91 +/- 1.57 mu g/mL). The tested cyclohexane and dichloromethane extracts possessed moderate antibacterial and significant cytotoxic activity against both malignant (HeLa and N87) and healthy (MRC5) cell lines. Methanol extracts exhibited promising anti-Helicobacter activity without cytotoxicity against N87 and MRC5 cell lines.en
dc.publisherBegell House Inc, Danbury
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Medicinal Mushrooms
dc.titleAntimicrobial and Cytotoxic Activities of the Sulphur Shelf Medicinal Mushroom, Laetiporus sulphureus (Agaricomycetes), from Serbiaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГрозданић, Нада; Миленковић, Марина; Кундаковић, Татјана; Колунджић, Марија; Станојковић, Татјана; Динић, Мирослав; Којић, Милан; Голић, Наташа;
dc.citation.volume18
dc.citation.issue6
dc.citation.spage469
dc.citation.epage476
dc.citation.other18(6): 469-476
dc.citation.rankM23
dc.identifier.wos000386997500001
dc.identifier.doi10.1615/IntJMedMushrooms.v18.i6.10
dc.identifier.scopus2-s2.0-84986222835
dc.identifier.rcubconv_3692
dc.type.versionpublishedVersion


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