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Clopidogrel High On-Treatment Platelet Reactivity in Patients with Carotid Artery Stenosis Undergoing Endarterectomy. A Pilot Study
dc.creator | Backović, Dragana | |
dc.creator | Ignjatović, Svetlana | |
dc.creator | Rakicević, Ljiljana | |
dc.creator | Novković, Mirjana | |
dc.creator | Kusić-Tisma, Jelena | |
dc.creator | Radojković, Dragica | |
dc.creator | Strugarević, Evgenija | |
dc.creator | Čalija, Branko | |
dc.creator | Radak, Đorđe | |
dc.creator | Kovac, Mirjana | |
dc.date.accessioned | 2019-09-02T11:56:20Z | |
dc.date.available | 2019-09-02T11:56:20Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1570-1611 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2756 | |
dc.description.abstract | Objectives: A considerable number of patients do not achieve an adequate response to clopidogrel. Our study aimed to evaluate genetic and non-genetic factors as possible risks for clopidogrel high on-treatment platelet reactivity (HTPR) in patients (n=112) with carotid artery stenosis undergoing endarterectomy (CEA). Methods: Using multiple-electrode impedance aggregometry (MEA) the antiplatelet effectiveness of clopidogrel was measured after 24 h, 7 and 30 days of clopidogrel treatment, which was introduced after elective CEA at a dose of 75 mg daily, for at least 30 days. Results: HTPR was observed among 25% patients after clopidogrel therapy for 30 days. Further analysis showed that 53.3% of patients carrying the CYP2C19*2 gene variant had clopidogrel-HTPR, while in the wild type group there were 14.6% (p lt 0.001). Multivariate logistic regression analysis identified the CYP2C19*2 variant allele (OR 4.384; 95% CI 1.296-14.833, p=0.017) and high total cholesterol level (OR 2.090; 95% CI 1.263-3.459, p=0.004) as the only independent risk factors for clopidogrel-HTPR. Conclusion: The CYP2C19*2 gene variant and high total cholesterol level were major factors for clopidogrel-HTPR in patients with carotid artery stenosis undergoing CEA. | en |
dc.publisher | Bentham Science Publ Ltd, Sharjah | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173008/RS// | |
dc.rights | restrictedAccess | |
dc.source | Current Vascular Pharmacology | |
dc.title | Clopidogrel High On-Treatment Platelet Reactivity in Patients with Carotid Artery Stenosis Undergoing Endarterectomy. A Pilot Study | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Ракицевић, Љиљана; Радојковић, Драгица; Игњатовић, Светлана; Чалија, Бранко; Кусић-Тисма, Јелена; Ковац, Мирјана; Радак, Ђорђе; Новковић, Мирјана; Стругаревић, Евгенија; Бацковић, Драгана; | |
dc.citation.volume | 14 | |
dc.citation.issue | 6 | |
dc.citation.spage | 563 | |
dc.citation.epage | 569 | |
dc.citation.other | 14(6): 563-569 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000387077100009 | |
dc.identifier.doi | 10.2174/1570161114666160714103148 | |
dc.identifier.pmid | 27411384 | |
dc.identifier.scopus | 2-s2.0-84995584818 | |
dc.type.version | publishedVersion |
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