Приказ основних података о документу

dc.creatorBacković, Dragana
dc.creatorIgnjatović, Svetlana
dc.creatorRakicević, Ljiljana
dc.creatorNovković, Mirjana
dc.creatorKusić-Tisma, Jelena
dc.creatorRadojković, Dragica
dc.creatorStrugarević, Evgenija
dc.creatorČalija, Branko
dc.creatorRadak, Đorđe
dc.creatorKovac, Mirjana
dc.date.accessioned2019-09-02T11:56:20Z
dc.date.available2019-09-02T11:56:20Z
dc.date.issued2016
dc.identifier.issn1570-1611
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2756
dc.description.abstractObjectives: A considerable number of patients do not achieve an adequate response to clopidogrel. Our study aimed to evaluate genetic and non-genetic factors as possible risks for clopidogrel high on-treatment platelet reactivity (HTPR) in patients (n=112) with carotid artery stenosis undergoing endarterectomy (CEA). Methods: Using multiple-electrode impedance aggregometry (MEA) the antiplatelet effectiveness of clopidogrel was measured after 24 h, 7 and 30 days of clopidogrel treatment, which was introduced after elective CEA at a dose of 75 mg daily, for at least 30 days. Results: HTPR was observed among 25% patients after clopidogrel therapy for 30 days. Further analysis showed that 53.3% of patients carrying the CYP2C19*2 gene variant had clopidogrel-HTPR, while in the wild type group there were 14.6% (p lt 0.001). Multivariate logistic regression analysis identified the CYP2C19*2 variant allele (OR 4.384; 95% CI 1.296-14.833, p=0.017) and high total cholesterol level (OR 2.090; 95% CI 1.263-3.459, p=0.004) as the only independent risk factors for clopidogrel-HTPR. Conclusion: The CYP2C19*2 gene variant and high total cholesterol level were major factors for clopidogrel-HTPR in patients with carotid artery stenosis undergoing CEA.en
dc.publisherBentham Science Publ Ltd, Sharjah
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173008/RS//
dc.rightsrestrictedAccess
dc.sourceCurrent Vascular Pharmacology
dc.titleClopidogrel High On-Treatment Platelet Reactivity in Patients with Carotid Artery Stenosis Undergoing Endarterectomy. A Pilot Studyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРакицевић, Љиљана; Радојковић, Драгица; Игњатовић, Светлана; Чалија, Бранко; Кусић-Тисма, Јелена; Ковац, Мирјана; Радак, Ђорђе; Новковић, Мирјана; Стругаревић, Евгенија; Бацковић, Драгана;
dc.citation.volume14
dc.citation.issue6
dc.citation.spage563
dc.citation.epage569
dc.citation.other14(6): 563-569
dc.citation.rankM22
dc.identifier.wos000387077100009
dc.identifier.doi10.2174/1570161114666160714103148
dc.identifier.pmid27411384
dc.identifier.scopus2-s2.0-84995584818
dc.type.versionpublishedVersion


Документи

ДатотекеВеличинаФорматПреглед

Уз овај запис нема датотека.

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу