Copeptin Levels Do Not Correlate With Cross-Clamping Time in Patients Undergoing Carotid Endarterectomy Under General Anesthesia
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2016
Authors
Unić-Stojanović, DraganaIsenović, Esma
Jović, Miomir
Maravić-Stojković, Vera

Miljković, Milica

Gojković, Tamara

Milicić, Biljana
Bogdanović, Nikola

Radak, Đorđe
Article (Published version)

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Copeptin is a sensitive and more stable surrogate marker for arginine vasopressin. In this study, we evaluated copeptin levels in carotid endarterectomy (CEA) patients, perioperatively, to determine whether copeptin levels can be related to carotid artery cross clamping (CC) time and to postoperative neurological outcomes. Copeptin, interleukin 6, C-reactive protein, cortisol, and brain natriuretic peptide were measured preoperatively (T1) and 3 hours postoperatively (T3) as well as intraoperatively (T2). We recruited 77 patients. Values of copeptin rose gradually over the observed times: T1 = 7.9 (6.4-9.6), T2 = 12.6 (9.3-16.8), and T3 = 72.3 (49.1-111.2) pmol/L. There was a significant difference for repeated measurement (P = .000, P = .000, and P = .000). Duration of carotid artery CC during CEA does not affect postoperative copeptin level (CC 13 minutes: 106.8 +/- 93.6 pmol/L, CC > 13 minutes: 96.7 +/- 89.1 pmol/L; P = .634). Preoperative copeptin level was significantly higher in ...patients with ulcerated plaque morphology. Activation of the stress axis in patients undergoing CEA results in copeptin elevation. Duration of CC during CEA does not affect postoperative copeptin levels.
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Angiology, 2016, 67, 10, 951-960Publisher:
- Sage Publications Inc, Thousand Oaks
Funding / projects:
DOI: 10.1177/0003319716629322
ISSN: 0003-3197
PubMed: 26843542
WoS: 000386036600011
Scopus: 2-s2.0-84990855378
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PharmacyTY - JOUR AU - Unić-Stojanović, Dragana AU - Isenović, Esma AU - Jović, Miomir AU - Maravić-Stojković, Vera AU - Miljković, Milica AU - Gojković, Tamara AU - Milicić, Biljana AU - Bogdanović, Nikola AU - Radak, Đorđe PY - 2016 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2758 AB - Copeptin is a sensitive and more stable surrogate marker for arginine vasopressin. In this study, we evaluated copeptin levels in carotid endarterectomy (CEA) patients, perioperatively, to determine whether copeptin levels can be related to carotid artery cross clamping (CC) time and to postoperative neurological outcomes. Copeptin, interleukin 6, C-reactive protein, cortisol, and brain natriuretic peptide were measured preoperatively (T1) and 3 hours postoperatively (T3) as well as intraoperatively (T2). We recruited 77 patients. Values of copeptin rose gradually over the observed times: T1 = 7.9 (6.4-9.6), T2 = 12.6 (9.3-16.8), and T3 = 72.3 (49.1-111.2) pmol/L. There was a significant difference for repeated measurement (P = .000, P = .000, and P = .000). Duration of carotid artery CC during CEA does not affect postoperative copeptin level (CC 13 minutes: 106.8 +/- 93.6 pmol/L, CC > 13 minutes: 96.7 +/- 89.1 pmol/L; P = .634). Preoperative copeptin level was significantly higher in patients with ulcerated plaque morphology. Activation of the stress axis in patients undergoing CEA results in copeptin elevation. Duration of CC during CEA does not affect postoperative copeptin levels. PB - Sage Publications Inc, Thousand Oaks T2 - Angiology T1 - Copeptin Levels Do Not Correlate With Cross-Clamping Time in Patients Undergoing Carotid Endarterectomy Under General Anesthesia VL - 67 IS - 10 SP - 951 EP - 960 DO - 10.1177/0003319716629322 ER -
@article{ author = "Unić-Stojanović, Dragana and Isenović, Esma and Jović, Miomir and Maravić-Stojković, Vera and Miljković, Milica and Gojković, Tamara and Milicić, Biljana and Bogdanović, Nikola and Radak, Đorđe", year = "2016", abstract = "Copeptin is a sensitive and more stable surrogate marker for arginine vasopressin. In this study, we evaluated copeptin levels in carotid endarterectomy (CEA) patients, perioperatively, to determine whether copeptin levels can be related to carotid artery cross clamping (CC) time and to postoperative neurological outcomes. Copeptin, interleukin 6, C-reactive protein, cortisol, and brain natriuretic peptide were measured preoperatively (T1) and 3 hours postoperatively (T3) as well as intraoperatively (T2). We recruited 77 patients. Values of copeptin rose gradually over the observed times: T1 = 7.9 (6.4-9.6), T2 = 12.6 (9.3-16.8), and T3 = 72.3 (49.1-111.2) pmol/L. There was a significant difference for repeated measurement (P = .000, P = .000, and P = .000). Duration of carotid artery CC during CEA does not affect postoperative copeptin level (CC 13 minutes: 106.8 +/- 93.6 pmol/L, CC > 13 minutes: 96.7 +/- 89.1 pmol/L; P = .634). Preoperative copeptin level was significantly higher in patients with ulcerated plaque morphology. Activation of the stress axis in patients undergoing CEA results in copeptin elevation. Duration of CC during CEA does not affect postoperative copeptin levels.", publisher = "Sage Publications Inc, Thousand Oaks", journal = "Angiology", title = "Copeptin Levels Do Not Correlate With Cross-Clamping Time in Patients Undergoing Carotid Endarterectomy Under General Anesthesia", volume = "67", number = "10", pages = "951-960", doi = "10.1177/0003319716629322" }
Unić-Stojanović, D., Isenović, E., Jović, M., Maravić-Stojković, V., Miljković, M., Gojković, T., Milicić, B., Bogdanović, N.,& Radak, Đ.. (2016). Copeptin Levels Do Not Correlate With Cross-Clamping Time in Patients Undergoing Carotid Endarterectomy Under General Anesthesia. in Angiology Sage Publications Inc, Thousand Oaks., 67(10), 951-960. https://doi.org/10.1177/0003319716629322
Unić-Stojanović D, Isenović E, Jović M, Maravić-Stojković V, Miljković M, Gojković T, Milicić B, Bogdanović N, Radak Đ. Copeptin Levels Do Not Correlate With Cross-Clamping Time in Patients Undergoing Carotid Endarterectomy Under General Anesthesia. in Angiology. 2016;67(10):951-960. doi:10.1177/0003319716629322 .
Unić-Stojanović, Dragana, Isenović, Esma, Jović, Miomir, Maravić-Stojković, Vera, Miljković, Milica, Gojković, Tamara, Milicić, Biljana, Bogdanović, Nikola, Radak, Đorđe, "Copeptin Levels Do Not Correlate With Cross-Clamping Time in Patients Undergoing Carotid Endarterectomy Under General Anesthesia" in Angiology, 67, no. 10 (2016):951-960, https://doi.org/10.1177/0003319716629322 . .