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dc.creatorAngelova, Violina T.
dc.creatorVassilev, Nikolay G.
dc.creatorNikolova-Mladenova, Boryana
dc.creatorVitas, Jasmina
dc.creatorMalbasa, Radomir
dc.creatorMomekov, Georgi
dc.creatorĐukić, Mirjana
dc.creatorSaso, Luciano
dc.date.accessioned2019-09-02T11:56:27Z
dc.date.available2019-09-02T11:56:27Z
dc.date.issued2016
dc.identifier.issn1054-2523
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2760
dc.description.abstractA series of new hybrid molecules with a hydrazone fragment were synthesized and characterized by Fourier transform-infrared spectroscopy, nuclear magnetic resonance, mass spectrometry, and elemental analysis. The nuclear magnetic resonance spectra of the hydrazones 4a-c showed exchange of syn and antiperiplanar conformers around the amide bond, the more stable being the antiperiplanar one. The nuclear Overhauser effect spectroscopy (NOESY) spectra confirm E configuration around C=N bond. The tested compounds exhibited concentration-dependent cytotoxic effects against human tumor cell lines in a micromolar range (MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay). Hydrazone 4a proved to be the most potent antiproliferative agent of the series. Within the antioxidant screening 8b exhibited the highest radical scavenging activity (% RSA max) and the largest rate constant for the reaction with 2,2-diphenyl-1-picrylhydrazyl.en
dc.publisherSpringer Birkhauser, New York
dc.relationNational Research Fund of Bulgaria - UNA-17/2005
dc.rightsrestrictedAccess
dc.sourceMedicinal Chemistry Research
dc.titleAntiproliferative and antioxidative effects of novel hydrazone derivatives bearing coumarin and chromene moietyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВассилев, Николаy Г.; Ђукић, Мирјана; Малбаса, Радомир; Витас, Јасмина; Сасо, Луциано; Николова-Младенова, Борyана; Момеков, Георги; Aнгелова, Виолина Т.;
dc.citation.volume25
dc.citation.issue9
dc.citation.spage2082
dc.citation.epage2092
dc.citation.other25(9): 2082-2092
dc.citation.rankM23
dc.identifier.wos000385175500030
dc.identifier.doi10.1007/s00044-016-1661-4
dc.identifier.scopus2-s2.0-84979586929
dc.identifier.rcubconv_3680
dc.type.versionpublishedVersion


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