FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrillic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Formulation and physicochemical characterization of hydrogels with 18 beta-glycyrrhetinic acid/phospholipid complex phytosomes

Authorized Users Only
2016
Authors
Đekić, Ljiljana
Krajišnik, Danina
Micić, Zorica
Čalija, Bojan
Article (Published version)
Metadata
Show full item record
Abstract
Carbomer based hydrogels with 1% of 18 beta-glycyrrhetinic acid complex in the form of phytosomes (18 beta-GAP) were formulated by using Carbopol (R) 980 and Carbopol (R) Ultrez 10 as gelling agents (1%), sodium hydroxide (neutralizing agent) (0.4%), glycerol (humectant) (10%), Sepicide (R) HB (preservative) (1%), and water (up to 100%). In order to prepare the hydrogels, 18 beta-GAP was dispersed into the water phase prior the carbomer neutralization or the 18 beta-GAP aqueous dispersion was added into the previously neutralized carbomer dispersion. The pH values (6.71 +/- 0.16-7.09 +/- 0.06), soft semisolid consistency and spreadability (25.7 +/- 1.5 mm-33.7 +/- 0.6 mm) of the hydrogels were acceptable for application on the skin. The influence of the preparation procedure, the carbomer type, and addition of a humectant (glycerol 10%) on physicochemical properties was evaluated using light microscopy, DSC analysis and rheological behavior characterization. The preparation procedure, ...the carbomer type, and the addition of the humectant did not affect significantly organoleptic and morphological characteristics and spread-ability of the hydrogels. The Carbopol (R) 980 based hydrogels were more sensitive than hydrogels based on Carbopol (R) Ultrez 10 upon thermal variations regarding the water evaporation loss. Physical stability of the investigated hydrogels was satisfactory for minimum 30 days of storage at a temperature range from +4 degrees C up to +40 degrees C.

Source:
Journal of Drug Delivery Science and Technology, 2016, 35, 81-90
Publisher:
  • Elsevier Science BV, Amsterdam
Funding / projects:
  • Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness (RS-46010)

DOI: 10.1016/j.jddst.2016.06.008

ISSN: 1773-2247

WoS: 000385598600011

Scopus: 2-s2.0-84976351782
[ Google Scholar ]
19
14
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2762
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Đekić, Ljiljana
AU  - Krajišnik, Danina
AU  - Micić, Zorica
AU  - Čalija, Bojan
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2762
AB  - Carbomer based hydrogels with 1% of 18 beta-glycyrrhetinic acid complex in the form of phytosomes (18 beta-GAP) were formulated by using Carbopol (R) 980 and Carbopol (R) Ultrez 10 as gelling agents (1%), sodium hydroxide (neutralizing agent) (0.4%), glycerol (humectant) (10%), Sepicide (R) HB (preservative) (1%), and water (up to 100%). In order to prepare the hydrogels, 18 beta-GAP was dispersed into the water phase prior the carbomer neutralization or the 18 beta-GAP aqueous dispersion was added into the previously neutralized carbomer dispersion. The pH values (6.71 +/- 0.16-7.09 +/- 0.06), soft semisolid consistency and spreadability (25.7 +/- 1.5 mm-33.7 +/- 0.6 mm) of the hydrogels were acceptable for application on the skin. The influence of the preparation procedure, the carbomer type, and addition of a humectant (glycerol 10%) on physicochemical properties was evaluated using light microscopy, DSC analysis and rheological behavior characterization. The preparation procedure, the carbomer type, and the addition of the humectant did not affect significantly organoleptic and morphological characteristics and spread-ability of the hydrogels. The Carbopol (R) 980 based hydrogels were more sensitive than hydrogels based on Carbopol (R) Ultrez 10 upon thermal variations regarding the water evaporation loss. Physical stability of the investigated hydrogels was satisfactory for minimum 30 days of storage at a temperature range from +4 degrees C up to +40 degrees C.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Drug Delivery Science and Technology
T1  - Formulation and physicochemical characterization of hydrogels with 18 beta-glycyrrhetinic acid/phospholipid complex phytosomes
VL  - 35
SP  - 81
EP  - 90
DO  - 10.1016/j.jddst.2016.06.008
ER  - 
@article{
author = "Đekić, Ljiljana and Krajišnik, Danina and Micić, Zorica and Čalija, Bojan",
year = "2016",
abstract = "Carbomer based hydrogels with 1% of 18 beta-glycyrrhetinic acid complex in the form of phytosomes (18 beta-GAP) were formulated by using Carbopol (R) 980 and Carbopol (R) Ultrez 10 as gelling agents (1%), sodium hydroxide (neutralizing agent) (0.4%), glycerol (humectant) (10%), Sepicide (R) HB (preservative) (1%), and water (up to 100%). In order to prepare the hydrogels, 18 beta-GAP was dispersed into the water phase prior the carbomer neutralization or the 18 beta-GAP aqueous dispersion was added into the previously neutralized carbomer dispersion. The pH values (6.71 +/- 0.16-7.09 +/- 0.06), soft semisolid consistency and spreadability (25.7 +/- 1.5 mm-33.7 +/- 0.6 mm) of the hydrogels were acceptable for application on the skin. The influence of the preparation procedure, the carbomer type, and addition of a humectant (glycerol 10%) on physicochemical properties was evaluated using light microscopy, DSC analysis and rheological behavior characterization. The preparation procedure, the carbomer type, and the addition of the humectant did not affect significantly organoleptic and morphological characteristics and spread-ability of the hydrogels. The Carbopol (R) 980 based hydrogels were more sensitive than hydrogels based on Carbopol (R) Ultrez 10 upon thermal variations regarding the water evaporation loss. Physical stability of the investigated hydrogels was satisfactory for minimum 30 days of storage at a temperature range from +4 degrees C up to +40 degrees C.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Drug Delivery Science and Technology",
title = "Formulation and physicochemical characterization of hydrogels with 18 beta-glycyrrhetinic acid/phospholipid complex phytosomes",
volume = "35",
pages = "81-90",
doi = "10.1016/j.jddst.2016.06.008"
}
Đekić, L., Krajišnik, D., Micić, Z.,& Čalija, B.. (2016). Formulation and physicochemical characterization of hydrogels with 18 beta-glycyrrhetinic acid/phospholipid complex phytosomes. in Journal of Drug Delivery Science and Technology
Elsevier Science BV, Amsterdam., 35, 81-90.
https://doi.org/10.1016/j.jddst.2016.06.008
Đekić L, Krajišnik D, Micić Z, Čalija B. Formulation and physicochemical characterization of hydrogels with 18 beta-glycyrrhetinic acid/phospholipid complex phytosomes. in Journal of Drug Delivery Science and Technology. 2016;35:81-90.
doi:10.1016/j.jddst.2016.06.008 .
Đekić, Ljiljana, Krajišnik, Danina, Micić, Zorica, Čalija, Bojan, "Formulation and physicochemical characterization of hydrogels with 18 beta-glycyrrhetinic acid/phospholipid complex phytosomes" in Journal of Drug Delivery Science and Technology, 35 (2016):81-90,
https://doi.org/10.1016/j.jddst.2016.06.008 . .

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceCommunitiesAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB