Приказ основних података о документу

dc.creatorĐekić, Ljiljana
dc.creatorKrajišnik, Danina
dc.creatorMicić, Zorica
dc.creatorČalija, Bojan
dc.date.accessioned2019-09-02T11:56:29Z
dc.date.available2019-09-02T11:56:29Z
dc.date.issued2016
dc.identifier.issn1773-2247
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2762
dc.description.abstractCarbomer based hydrogels with 1% of 18 beta-glycyrrhetinic acid complex in the form of phytosomes (18 beta-GAP) were formulated by using Carbopol (R) 980 and Carbopol (R) Ultrez 10 as gelling agents (1%), sodium hydroxide (neutralizing agent) (0.4%), glycerol (humectant) (10%), Sepicide (R) HB (preservative) (1%), and water (up to 100%). In order to prepare the hydrogels, 18 beta-GAP was dispersed into the water phase prior the carbomer neutralization or the 18 beta-GAP aqueous dispersion was added into the previously neutralized carbomer dispersion. The pH values (6.71 +/- 0.16-7.09 +/- 0.06), soft semisolid consistency and spreadability (25.7 +/- 1.5 mm-33.7 +/- 0.6 mm) of the hydrogels were acceptable for application on the skin. The influence of the preparation procedure, the carbomer type, and addition of a humectant (glycerol 10%) on physicochemical properties was evaluated using light microscopy, DSC analysis and rheological behavior characterization. The preparation procedure, the carbomer type, and the addition of the humectant did not affect significantly organoleptic and morphological characteristics and spread-ability of the hydrogels. The Carbopol (R) 980 based hydrogels were more sensitive than hydrogels based on Carbopol (R) Ultrez 10 upon thermal variations regarding the water evaporation loss. Physical stability of the investigated hydrogels was satisfactory for minimum 30 days of storage at a temperature range from +4 degrees C up to +40 degrees C.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Drug Delivery Science and Technology
dc.titleFormulation and physicochemical characterization of hydrogels with 18 beta-glycyrrhetinic acid/phospholipid complex phytosomesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЂекић, Љиљана; Крајишник, Данина; Чалија, Бојан; Мицић, Зорица;
dc.citation.volume35
dc.citation.spage81
dc.citation.epage90
dc.citation.other35: 81-90
dc.citation.rankM23
dc.identifier.wos000385598600011
dc.identifier.doi10.1016/j.jddst.2016.06.008
dc.identifier.scopus2-s2.0-84976351782
dc.type.versionpublishedVersion


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Приказ основних података о документу