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Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea

Authorized Users Only
2016
Authors
Vekić, Jelena
Joppa, Pavol
Habalova, Viera
Tisko, Radovan
Zeljković, Aleksandra
Pobeha, Pavol
Gojković, Tamara
Spasojević-Kalimanovska, Vesna
Strbova, Zuzana
Kuklisova, Zuzana
Slaba, Eva
Rizzo, Manfredi
Tkacova, Ruzena
Article (Published version)
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Abstract
Obstructive sleep apnea (OSA) is associated with dyslipidemia and increased cardiovascular risk. We assessed the effects of apolipoprotein E (APOE) genotype on low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle size and lipid subclasses (separated by gradient gel electrophoresis) in patients with OSA. Stable patients (n = 181) prospectively recruited underwent full polysomnography. Both LDL particle size and LDL I proportion were reduced from 33 homozygotes to 2 carriers and to 4 carriers (analysis of variance: P = .024; P = .040, respectively); carriers of the 4 allele of the APOE genotype had significantly lower LDL particle size and LDL I proportion compared to 33 homozygotes (P lt .05 for both comparisons). Insulin resistance increased from patients with no OSA to those with mild-moderate and to those with severe OSA (P lt .001). In multivariate analysis, LDL size was independently predicted by APOE genotype, male gender, and the presence of metabolic syn...drome (MetS; P = .001, P = .020, P = .027, respectively). The HDL particle size was not affected by APOE genotype. Our data demonstrate that both the 4 APOE genotype and MetS are independently related to smaller LDL size in patients with OSA.

Source:
Angiology, 2016, 67, 10, 937-944
Publisher:
  • Sage Publications Inc, Thousand Oaks
Projects:
  • Slovak Research and Development Agency of the Ministry of Education, Slovakia - VEGA 1/0863/15

DOI: 10.1177/0003319716636512

ISSN: 0003-3197

PubMed: 26941371

WoS: 000386036600009

Scopus: 2-s2.0-84990852858
[ Google Scholar ]
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2765
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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