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dc.creatorVekić, Jelena
dc.creatorJoppa, Pavol
dc.creatorHabalova, Viera
dc.creatorTisko, Radovan
dc.creatorZeljković, Aleksandra
dc.creatorPobeha, Pavol
dc.creatorGojković, Tamara
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorStrbova, Zuzana
dc.creatorKuklisova, Zuzana
dc.creatorSlaba, Eva
dc.creatorRizzo, Manfredi
dc.creatorTkacova, Ruzena
dc.date.accessioned2019-09-02T11:56:35Z
dc.date.available2019-09-02T11:56:35Z
dc.date.issued2016
dc.identifier.issn0003-3197
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2765
dc.description.abstractObstructive sleep apnea (OSA) is associated with dyslipidemia and increased cardiovascular risk. We assessed the effects of apolipoprotein E (APOE) genotype on low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle size and lipid subclasses (separated by gradient gel electrophoresis) in patients with OSA. Stable patients (n = 181) prospectively recruited underwent full polysomnography. Both LDL particle size and LDL I proportion were reduced from 33 homozygotes to 2 carriers and to 4 carriers (analysis of variance: P = .024; P = .040, respectively); carriers of the 4 allele of the APOE genotype had significantly lower LDL particle size and LDL I proportion compared to 33 homozygotes (P lt .05 for both comparisons). Insulin resistance increased from patients with no OSA to those with mild-moderate and to those with severe OSA (P lt .001). In multivariate analysis, LDL size was independently predicted by APOE genotype, male gender, and the presence of metabolic syndrome (MetS; P = .001, P = .020, P = .027, respectively). The HDL particle size was not affected by APOE genotype. Our data demonstrate that both the 4 APOE genotype and MetS are independently related to smaller LDL size in patients with OSA.en
dc.publisherSage Publications Inc, Thousand Oaks
dc.relationSlovak Research and Development Agency of the Ministry of Education, Slovakia - VEGA 1/0863/15
dc.rightsrestrictedAccess
dc.sourceAngiology
dc.titleRelationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apneaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРиззо, Манфреди; Ткацова, Рузена; Слаба, Ева; Стрбова, Зузана; Гојковић, Тамара; Куклисова, Зузана; Векић, Јелена; Јоппа, Павол; Хабалова, Виера; Тиско, Радован; Зељковић, Aлександра; Спасојевић-Калимановска, Весна; Побеха, Павол;
dc.citation.volume67
dc.citation.issue10
dc.citation.spage937
dc.citation.epage944
dc.citation.other67(10): 937-944
dc.citation.rankM22
dc.identifier.wos000386036600009
dc.identifier.doi10.1177/0003319716636512
dc.identifier.pmid26941371
dc.identifier.scopus2-s2.0-84990852858
dc.identifier.rcubconv_3684
dc.type.versionpublishedVersion


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