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Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy

Authorized Users Only
2016
Authors
Ilić, V
Bogićević, Dragana
Miljković, Branislava
Ješić, M
Kovačević, M
Prostran, Milica
Vezmar-Kovačević, Sandra
Article (Published version)
Metadata
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Abstract
Aim. To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy. Methods. Serumlevels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine, thyreoglobulin antibodies, and thyroid peroxidase antibodies were determined in 41 patients and in 41 sex- And age-matched healthy children. Results. Meanvalproic acid treatment durationwas 2.80?}1.96 years. The valproic acid group had higher serum thyroid-stimulating hormone (p lt 0.001) and free triiodothyronine (p lt 0.05) levels compared to the control group. Serum thyroid-stimulating hormone and free triiodothyronine were above the upper limit for healthy controls in 34% and 32% of patients, respectively, and no clinical features of thyroid dysfunction were observed. Duration of valproic acid monotherapy for less than four years was a risk factor for elevated thyroid-stimulating hormone levels. Conclusion. One third of children wi...th normal range serum valproic acid levels may have elevated serum thyroid-stimulating hormone and free triiodothyronine levels, especially in the first four years of treatment.

Keywords:
Children / Epilepsy / Thyroid function / Valproic acid
Source:
Epileptic Disorders, 2016, 18, 2, 181-186
Publisher:
  • John Libbey Eurotext
Projects:
  • Basic and Clinical Pharmacological research of mechanisms of action and drug interactions in nervous and cardiovascular system (RS-175023)

DOI: 10.1684/epd.2016.0821

ISSN: 1294-9361

Scopus: 2-s2.0-84976427915
[ Google Scholar ]
1
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2767
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy
TY  - JOUR
AU  - Ilić, V
AU  - Bogićević, Dragana
AU  - Miljković, Branislava
AU  - Ješić, M
AU  - Kovačević, M
AU  - Prostran, Milica
AU  - Vezmar-Kovačević, Sandra
PY  - 2016
UR  - http://farfar.pharmacy.bg.ac.rs/handle/123456789/2767
AB  - Aim. To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy. Methods. Serumlevels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine, thyreoglobulin antibodies, and thyroid peroxidase antibodies were determined in 41 patients and in 41 sex- And age-matched healthy children. Results. Meanvalproic acid treatment durationwas 2.80?}1.96 years. The valproic acid group had higher serum thyroid-stimulating hormone (p lt 0.001) and free triiodothyronine (p lt 0.05) levels compared to the control group. Serum thyroid-stimulating hormone and free triiodothyronine were above the upper limit for healthy controls in 34% and 32% of patients, respectively, and no clinical features of thyroid dysfunction were observed. Duration of valproic acid monotherapy for less than four years was a risk factor for elevated thyroid-stimulating hormone levels. Conclusion. One third of children with normal range serum valproic acid levels may have elevated serum thyroid-stimulating hormone and free triiodothyronine levels, especially in the first four years of treatment.
PB  - John Libbey Eurotext
T2  - Epileptic Disorders
T1  - Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy
VL  - 18
IS  - 2
SP  - 181
EP  - 186
DO  - 10.1684/epd.2016.0821
ER  - 
@article{
author = "Ilić, V and Bogićević, Dragana and Miljković, Branislava and Ješić, M and Kovačević, M and Prostran, Milica and Vezmar-Kovačević, Sandra",
year = "2016",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/2767",
abstract = "Aim. To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy. Methods. Serumlevels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine, thyreoglobulin antibodies, and thyroid peroxidase antibodies were determined in 41 patients and in 41 sex- And age-matched healthy children. Results. Meanvalproic acid treatment durationwas 2.80?}1.96 years. The valproic acid group had higher serum thyroid-stimulating hormone (p lt 0.001) and free triiodothyronine (p lt 0.05) levels compared to the control group. Serum thyroid-stimulating hormone and free triiodothyronine were above the upper limit for healthy controls in 34% and 32% of patients, respectively, and no clinical features of thyroid dysfunction were observed. Duration of valproic acid monotherapy for less than four years was a risk factor for elevated thyroid-stimulating hormone levels. Conclusion. One third of children with normal range serum valproic acid levels may have elevated serum thyroid-stimulating hormone and free triiodothyronine levels, especially in the first four years of treatment.",
publisher = "John Libbey Eurotext",
journal = "Epileptic Disorders",
title = "Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy",
volume = "18",
number = "2",
pages = "181-186",
doi = "10.1684/epd.2016.0821"
}
Ilić V, Bogićević D, Miljković B, Ješić M, Kovačević M, Prostran M, Vezmar-Kovačević S. Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy. Epileptic Disorders. 2016;18(2):181-186
Ilić, V., Bogićević, D., Miljković, B., Ješić, M., Kovačević, M., Prostran, M.,& Vezmar-Kovačević, S. (2016). Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy.
Epileptic DisordersJohn Libbey Eurotext., 18(2), 181-186.
https://doi.org/10.1684/epd.2016.0821
Ilić V, Bogićević Dragana, Miljković Branislava, Ješić M, Kovačević M, Prostran Milica, Vezmar-Kovačević Sandra, "Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy" 18, no. 2 (2016):181-186,
https://doi.org/10.1684/epd.2016.0821 .

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