Aim. To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy. Methods. Serumlevels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine, thyreoglobulin antibodies, and thyroid peroxidase antibodies were determined in 41 patients and in 41 sex- And age-matched healthy children. Results. Meanvalproic acid treatment durationwas 2.80?}1.96 years. The valproic acid group had higher serum thyroid-stimulating hormone (p lt 0.001) and free triiodothyronine (p lt 0.05) levels compared to the control group. Serum thyroid-stimulating hormone and free triiodothyronine were above the upper limit for healthy controls in 34% and 32% of patients, respectively, and no clinical features of thyroid dysfunction were observed. Duration of valproic acid monotherapy for less than four years was a risk factor for elevated thyroid-stimulating hormone levels. Conclusion. One third of children wi...th normal range serum valproic acid levels may have elevated serum thyroid-stimulating hormone and free triiodothyronine levels, especially in the first four years of treatment.
Keywords:
Children / Epilepsy / Thyroid function / Valproic acid
TY - JOUR
AU - Ilić, V
AU - Bogićević, Dragana
AU - Miljković, Branislava
AU - Ješić, M
AU - Kovačević, M
AU - Prostran, Milica
AU - Vezmar-Kovačević, Sandra
PY - 2016
UR - http://farfar.pharmacy.bg.ac.rs/handle/123456789/2767
AB - Aim. To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy. Methods. Serumlevels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine, thyreoglobulin antibodies, and thyroid peroxidase antibodies were determined in 41 patients and in 41 sex- And age-matched healthy children. Results. Meanvalproic acid treatment durationwas 2.80?}1.96 years. The valproic acid group had higher serum thyroid-stimulating hormone (p lt 0.001) and free triiodothyronine (p lt 0.05) levels compared to the control group. Serum thyroid-stimulating hormone and free triiodothyronine were above the upper limit for healthy controls in 34% and 32% of patients, respectively, and no clinical features of thyroid dysfunction were observed. Duration of valproic acid monotherapy for less than four years was a risk factor for elevated thyroid-stimulating hormone levels. Conclusion. One third of children with normal range serum valproic acid levels may have elevated serum thyroid-stimulating hormone and free triiodothyronine levels, especially in the first four years of treatment.
PB - John Libbey Eurotext
T2 - Epileptic Disorders
T1 - Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy
VL - 18
IS - 2
SP - 181
EP - 186
DO - 10.1684/epd.2016.0821
ER -
@article{
author = "Ilić, V and Bogićević, Dragana and Miljković, Branislava and Ješić, M and Kovačević, M and Prostran, Milica and Vezmar-Kovačević, Sandra",
year = "2016",
url = "http://farfar.pharmacy.bg.ac.rs/handle/123456789/2767",
abstract = "Aim. To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy. Methods. Serumlevels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine, thyreoglobulin antibodies, and thyroid peroxidase antibodies were determined in 41 patients and in 41 sex- And age-matched healthy children. Results. Meanvalproic acid treatment durationwas 2.80?}1.96 years. The valproic acid group had higher serum thyroid-stimulating hormone (p lt 0.001) and free triiodothyronine (p lt 0.05) levels compared to the control group. Serum thyroid-stimulating hormone and free triiodothyronine were above the upper limit for healthy controls in 34% and 32% of patients, respectively, and no clinical features of thyroid dysfunction were observed. Duration of valproic acid monotherapy for less than four years was a risk factor for elevated thyroid-stimulating hormone levels. Conclusion. One third of children with normal range serum valproic acid levels may have elevated serum thyroid-stimulating hormone and free triiodothyronine levels, especially in the first four years of treatment.",
publisher = "John Libbey Eurotext",
journal = "Epileptic Disorders",
title = "Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy",
volume = "18",
number = "2",
pages = "181-186",
doi = "10.1684/epd.2016.0821"
}
Ilić, V., Bogićević, D., Miljković, B., Ješić, M., Kovačević, M., Prostran, M.,& Vezmar-Kovačević, S. (2016). Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy.
Epileptic Disorders
John Libbey Eurotext., 18(2), 181-186.
https://doi.org/10.1684/epd.2016.0821
Ilić V, Bogićević D, Miljković B, Ješić M, Kovačević M, Prostran M, Vezmar-Kovačević S. Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy. Epileptic Disorders. 2016;18(2):181-186
Ilić V, Bogićević Dragana, Miljković Branislava, Ješić M, Kovačević M, Prostran Milica, Vezmar-Kovačević Sandra, "Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy" Epileptic Disorders, 18, no. 2 (2016):181-186,
https://doi.org/10.1684/epd.2016.0821 .
