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Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy
dc.creator | Ilić, V | |
dc.creator | Bogićević, Dragana | |
dc.creator | Miljković, Branislava | |
dc.creator | Ješić, M | |
dc.creator | Kovačević, M | |
dc.creator | Prostran, Milica | |
dc.creator | Vezmar-Kovačević, Sandra | |
dc.date.accessioned | 2019-09-02T11:56:38Z | |
dc.date.available | 2019-09-02T11:56:38Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1294-9361 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2767 | |
dc.description.abstract | Aim. To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy. Methods. Serumlevels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine, thyreoglobulin antibodies, and thyroid peroxidase antibodies were determined in 41 patients and in 41 sex- And age-matched healthy children. Results. Meanvalproic acid treatment durationwas 2.80?}1.96 years. The valproic acid group had higher serum thyroid-stimulating hormone (p lt 0.001) and free triiodothyronine (p lt 0.05) levels compared to the control group. Serum thyroid-stimulating hormone and free triiodothyronine were above the upper limit for healthy controls in 34% and 32% of patients, respectively, and no clinical features of thyroid dysfunction were observed. Duration of valproic acid monotherapy for less than four years was a risk factor for elevated thyroid-stimulating hormone levels. Conclusion. One third of children with normal range serum valproic acid levels may have elevated serum thyroid-stimulating hormone and free triiodothyronine levels, especially in the first four years of treatment. | en |
dc.publisher | John Libbey Eurotext | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175023/RS// | |
dc.rights | restrictedAccess | |
dc.source | Epileptic Disorders | |
dc.subject | Children | en |
dc.subject | Epilepsy | en |
dc.subject | Thyroid function | en |
dc.subject | Valproic acid | en |
dc.title | Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Простран, Милица; Ковачевић, М; Богићевић, Драгана; Илић, В; Миљковић, Бранислава; Јешић, М; Везмар-Ковачевић, Сандра; | |
dc.citation.volume | 18 | |
dc.citation.issue | 2 | |
dc.citation.spage | 181 | |
dc.citation.epage | 186 | |
dc.citation.other | 18(2): 181-186 | |
dc.citation.rank | M23 | |
dc.identifier.doi | 10.1684/epd.2016.0821 | |
dc.identifier.scopus | 2-s2.0-84976427915 | |
dc.type.version | publishedVersion |