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dc.creatorNovaković, Radmila
dc.creatorRadunović, Nebojša
dc.creatorRajković, Jovana
dc.creatorĐokić, Vladimir
dc.creatorPetrović, Aleksandar V.
dc.creatorIvković, Branka
dc.creatorĆupić, Vitomir
dc.creatorKanjuh, Vladimir
dc.creatorHelmut, Heinlev
dc.creatorGojković-Bukarica, Ljiljana
dc.date.accessioned2019-09-02T11:56:43Z
dc.date.available2019-09-02T11:56:43Z
dc.date.issued2016
dc.identifier.issn0350-2457
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2769
dc.description.abstractResveratrol is a phytoalexin produced in a number of plant species including grapes. The benefit of resveratrol to health is widely reported. Resveratrol has been found to promote relaxation of non-pregnant and pregnant uterus, but its mechanism of action is unclear. The aims of our study were to investigate the involvement of inwardly rectifying potassium channels (Kir) in inhibitory effects of resveratrol on three models of contractions of non-pregnant rat uterus: the spontaneous rhythmic contractions (SRC), oxytocin-elicited phasic contractions and tonic oxytocin-elicited contractions. Uterine strips were obtained from virgin female Wistar rats in oestrus. Strips were mounted into organ bath for recording isometric tension in Krebs-Ringer solution. Experiments followed a multiple curve design. In order to test the involvement of Kirchannels in a mechanism of action of resveratrol (1-100 μM),BaCl2 (1 mM),a antagonist of inwardly rectifying potassium channels was used. Resveratrol induced a concentration-dependent relaxation of all models of contractions. BaCl2 antagonized the response to resveratrolon SRC and oxytocin-elicited phasic contractions. Relaxation achieved by resveratrolon tonic oxytocin-elicited concentrations was insensitive to BaCl2.The antagonism of resveratrol effects by inwardly rectifying potassium channels antagonist suggests that Kir channels are involved in resveratrol action on phasic contractions of rat uterus. Inhibitory effect of resveratrol on tonic contractions did not include Kir channels.en
dc.publisherUniverzitet u Beogradu - Fakultet veterinarske medicine, Beograd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/31020/RS//
dc.rightsopenAccess
dc.sourceVeterinarski glasnik
dc.subjectresveratrrolen
dc.subjectuterusen
dc.subjectinwardly recifying potassium channelsen
dc.subjectKiren
dc.titleWine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channelsen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractЂокић, Владимир; Кањух, Владимир; Ћупић, Витомир; Радуновић, Небојша; Хелмут, Хеинлев; Петровић, Aлександар В.; Рајковић, Јована; Гојковић-Букарица, Љиљана; Ивковић, Бранка; Новаковић, Радмила;
dc.citation.volume70
dc.citation.issue3-4
dc.citation.spage121
dc.citation.epage129
dc.citation.other70(3-4): 121-129
dc.citation.rankM51
dc.identifier.doi10.2298/VETGL1604121N
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1409/2767.pdf
dc.identifier.rcubconv_708
dc.type.versionpublishedVersion


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