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dc.creatorTopić, Aleksandra
dc.creatorNagorni-Obradović, Ljudmila
dc.creatorFrancuski, Đorđe
dc.creatorLjujić, Mila
dc.creatorMalić, Živka
dc.creatorRadojković, Dragica
dc.date.accessioned2019-09-02T11:56:45Z
dc.date.available2019-09-02T11:56:45Z
dc.date.issued2016
dc.identifier.issn0006-2928
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2771
dc.description.abstractAlpha-1-antitrypsin deficiency (AATD) and tobacco smoke play a key role in the pathogenesis of early-onset emphysema. Differences in AATD-related chronic obstructive pulmonary disease stages imply the existence of modifying factors associated with disease severity. We present two male patients with emphysema caused by severe AATD (PiZZ genotype). Both are former smokers and have epoxide hydrolase low-activity phenotype. Extremely high level of oxidative stress (high urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine), increased inflammation (high serum CRP), and GSTP1 105Val mutation were found in patient with a worse lung function and prognosis. These data provide more evidence that oxidative stress-related gene variants and inflammation are associated with worse symptoms of AATD-related emphysema. Therefore, prevention against severe stage of AATD-related emphysema would include early identification of the risk gene variants, cessation or never smoking, and treatment with anti-inflammatory and anti-oxidant drugs. Additionally, urinary 8-oxodG could be a candidate for predictive biomarker for routine assessment of the oxidative stress level in AATD patients.en
dc.publisherSpringer/Plenum Publishers, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173008/RS//
dc.rightsrestrictedAccess
dc.sourceBiochemical Genetics
dc.titleOxidative Stress and Polymorphism of Xenobiotic-Metabolizing Enzymes in Two Patients with Severe Alpha-1-Antitrypsin Deficiencyen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРадојковић, Драгица; Љујић, Мила; Топиц, Aлександра; Малић, Живка; Нагорни-Обрадовић, Људмила; Француски, Ђорђе;
dc.citation.volume54
dc.citation.issue5
dc.citation.spage746
dc.citation.epage752
dc.citation.other54(5): 746-752
dc.citation.rankM23
dc.identifier.wos000383038400013
dc.identifier.doi10.1007/s10528-016-9748-7
dc.identifier.pmid27271084
dc.identifier.scopus2-s2.0-84986551099
dc.identifier.rcubconv_3658
dc.type.versionpublishedVersion


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