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dc.creatorPotparević, Biljana
dc.creatorBajić, V
dc.date.accessioned2019-09-02T10:52:58Z
dc.date.available2019-09-02T10:52:58Z
dc.date.issued2000
dc.identifier.issn1311-0160
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/277
dc.description.abstractPremature centromere separation (PCS) syndromes strongly support evidence that spatial and temporal organization of the cell cycle is crucial for maintaining genomic stability. To see if PCS as a genomic instability state can predispose cells to aneuploidy we have exposed lymphocytes to a anti-tumor agents Mitomycin C in a dose of 0,05 μM/ml; 0,15 μM/ml and 0,6 μM/ml, 8-CI-cAMP in a dose of 1 μM/ml; 5 μM/ml and 15 μM/ml and Taxol in a dose of 0,01 μM/ml; 0,05 μM/ml and 0,2 μM/ml or 24h using the CB-micronucleus test. Micronuclei were analyzed in 1000 bi-nuclear cells for each experimental and control group, thus Mitomycin C, Taxol and 8-Cl-cAMP induced an increase in the frequency of micronuclei in cells that where previously in the state of expressing PCS.en
dc.publisherMacedonian Academy of Sciences and Arts
dc.rightsopenAccess
dc.sourceBalkan Journal of Medical Genetics
dc.titlePremature centromere separation syndromes: A manifestation of genome instability?en
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractБајић, В; Потпаревић, Биљана;
dc.citation.volume3
dc.citation.issue3
dc.citation.spage19
dc.citation.epage22
dc.citation.other3(3): 19-22
dc.identifier.scopus2-s2.0-0034458280
dc.identifier.rcubconv_5299
dc.type.versionpublishedVersion


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