dc.creator | Potparević, Biljana | |
dc.creator | Bajić, V | |
dc.date.accessioned | 2019-09-02T10:52:58Z | |
dc.date.available | 2019-09-02T10:52:58Z | |
dc.date.issued | 2000 | |
dc.identifier.issn | 1311-0160 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/277 | |
dc.description.abstract | Premature centromere separation (PCS) syndromes strongly support evidence that spatial and temporal organization of the cell cycle is crucial for maintaining genomic stability. To see if PCS as a genomic instability state can predispose cells to aneuploidy we have exposed lymphocytes to a anti-tumor agents Mitomycin C in a dose of 0,05 μM/ml; 0,15 μM/ml and 0,6 μM/ml, 8-CI-cAMP in a dose of 1 μM/ml; 5 μM/ml and 15 μM/ml and Taxol in a dose of 0,01 μM/ml; 0,05 μM/ml and 0,2 μM/ml or 24h using the CB-micronucleus test. Micronuclei were analyzed in 1000 bi-nuclear cells for each experimental and control group, thus Mitomycin C, Taxol and 8-Cl-cAMP induced an increase in the frequency of micronuclei in cells that where previously in the state of expressing PCS. | en |
dc.publisher | Macedonian Academy of Sciences and Arts | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Balkan Journal of Medical Genetics | |
dc.title | Premature centromere separation syndromes: A manifestation of genome instability? | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Бајић, В; Потпаревић, Биљана; | |
dc.citation.volume | 3 | |
dc.citation.issue | 3 | |
dc.citation.spage | 19 | |
dc.citation.epage | 22 | |
dc.citation.other | 3(3): 19-22 | |
dc.identifier.scopus | 2-s2.0-0034458280 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_farfar_277 | |
dc.type.version | publishedVersion | |