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dc.creatorPotparević, Biljana
dc.creatorBajić, V
dc.date.accessioned2019-09-02T10:52:58Z
dc.date.available2019-09-02T10:52:58Z
dc.date.issued2000
dc.identifier.issn1311-0160
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/277
dc.description.abstractPremature centromere separation (PCS) syndromes strongly support evidence that spatial and temporal organization of the cell cycle is crucial for maintaining genomic stability. To see if PCS as a genomic instability state can predispose cells to aneuploidy we have exposed lymphocytes to a anti-tumor agents Mitomycin C in a dose of 0,05 μM/ml; 0,15 μM/ml and 0,6 μM/ml, 8-CI-cAMP in a dose of 1 μM/ml; 5 μM/ml and 15 μM/ml and Taxol in a dose of 0,01 μM/ml; 0,05 μM/ml and 0,2 μM/ml or 24h using the CB-micronucleus test. Micronuclei were analyzed in 1000 bi-nuclear cells for each experimental and control group, thus Mitomycin C, Taxol and 8-Cl-cAMP induced an increase in the frequency of micronuclei in cells that where previously in the state of expressing PCS.en
dc.publisherMacedonian Academy of Sciences and Arts
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceBalkan Journal of Medical Genetics
dc.titlePremature centromere separation syndromes: A manifestation of genome instability?en
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractБајић, В; Потпаревић, Биљана;
dc.citation.volume3
dc.citation.issue3
dc.citation.spage19
dc.citation.epage22
dc.citation.other3(3): 19-22
dc.identifier.scopus2-s2.0-0034458280
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_farfar_277
dc.type.versionpublishedVersion


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