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Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release
dc.creator | Čalija, Bojan | |
dc.creator | Milić, Jela | |
dc.creator | Janićijević, Jelena | |
dc.creator | Daković, Aleksandra | |
dc.creator | Krajišnik, Danina | |
dc.date.accessioned | 2019-09-02T11:57:05Z | |
dc.date.available | 2019-09-02T11:57:05Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0009-8558 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2784 | |
dc.description.abstract | This study investigated the potential of halloysite nanotubes (HNTs) to improve the sustained release properties of chitosan (CS) microparticles cross-linked ionically with tripolyphosphate (TPP). Composite CS-HNTs microparticles were obtained by a simple and eco-friendly procedure based on a coaxial extrusion technique. Prior to encapsulation, a water-soluble model drug, verapamil hydrochloride (VH), was adsorbed successfully on HNTs. The microparticles were characterized by optical microscopy, Fourier transform infrared (FTIR) spectroscopy, differential thermal analysis/thermogravimetric analysis (DTA/TG) and evaluated for encapsulation efficiency and drug-release properties. The composite particles had a slightly deformed spherical shape and micrometric size with average perimeters ranging from 485.4 +/- 13.3 to 492.4 +/- 11.9 mu m. The results of FTIR spectroscopy confirmed non-covalent interactions between CS and HNTs within composite particle structures. The DTA and TG studies revealed increased thermal stability of the composite particles in comparison to the CS-TPP particles. Drug adsorption on HNTs prior to encapsulation led to an increase in encapsulation efficiency from 19.6 +/- 2.9 to 84.3 +/- 1.9%. In contrast to the rapid release of encapsulated model drug from CS-TPP microparticles, the composite CS-HNTs microparticles released drug in a sustained manner, showing the best fit to the Bhaskar model. The results presented here imply that HNTs could be used to improve morphology, encapsulation efficiency and sustained drug-release properties of CS microparticles cross-linked ionically with TPP. | en |
dc.publisher | Mineralogical Soc, Twickenham | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clay Minerals | |
dc.subject | halloysite | en |
dc.subject | chitosan | en |
dc.subject | composites | en |
dc.subject | microparticles | en |
dc.subject | drug delivery | en |
dc.title | Ionically cross-linked chitosan-halloysite composite microparticles for sustained drug release | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Милић, Јела; Чалија, Бојан; Крајишник, Данина; Јанићијевић, Јелена; Даковић, Aлександра; | |
dc.citation.volume | 52 | |
dc.citation.issue | 4 | |
dc.citation.spage | 413 | |
dc.citation.epage | 426 | |
dc.citation.other | 52(4): 413-426 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000431691500001 | |
dc.identifier.doi | 10.1180/claymin.2017.052.04.01 | |
dc.identifier.scopus | 2-s2.0-85042654681 | |
dc.type.version | publishedVersion |