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dc.creatorČalija, Bojan
dc.creatorMilić, Jela
dc.creatorJanićijević, Jelena
dc.creatorDaković, Aleksandra
dc.creatorKrajišnik, Danina
dc.date.accessioned2019-09-02T11:57:05Z
dc.date.available2019-09-02T11:57:05Z
dc.date.issued2017
dc.identifier.issn0009-8558
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2784
dc.description.abstractThis study investigated the potential of halloysite nanotubes (HNTs) to improve the sustained release properties of chitosan (CS) microparticles cross-linked ionically with tripolyphosphate (TPP). Composite CS-HNTs microparticles were obtained by a simple and eco-friendly procedure based on a coaxial extrusion technique. Prior to encapsulation, a water-soluble model drug, verapamil hydrochloride (VH), was adsorbed successfully on HNTs. The microparticles were characterized by optical microscopy, Fourier transform infrared (FTIR) spectroscopy, differential thermal analysis/thermogravimetric analysis (DTA/TG) and evaluated for encapsulation efficiency and drug-release properties. The composite particles had a slightly deformed spherical shape and micrometric size with average perimeters ranging from 485.4 +/- 13.3 to 492.4 +/- 11.9 mu m. The results of FTIR spectroscopy confirmed non-covalent interactions between CS and HNTs within composite particle structures. The DTA and TG studies revealed increased thermal stability of the composite particles in comparison to the CS-TPP particles. Drug adsorption on HNTs prior to encapsulation led to an increase in encapsulation efficiency from 19.6 +/- 2.9 to 84.3 +/- 1.9%. In contrast to the rapid release of encapsulated model drug from CS-TPP microparticles, the composite CS-HNTs microparticles released drug in a sustained manner, showing the best fit to the Bhaskar model. The results presented here imply that HNTs could be used to improve morphology, encapsulation efficiency and sustained drug-release properties of CS microparticles cross-linked ionically with TPP.en
dc.publisherMineralogical Soc, Twickenham
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.rightsrestrictedAccess
dc.sourceClay Minerals
dc.subjecthalloysiteen
dc.subjectchitosanen
dc.subjectcompositesen
dc.subjectmicroparticlesen
dc.subjectdrug deliveryen
dc.titleIonically cross-linked chitosan-halloysite composite microparticles for sustained drug releaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМилић, Јела; Чалија, Бојан; Крајишник, Данина; Јанићијевић, Јелена; Даковић, Aлександра;
dc.citation.volume52
dc.citation.issue4
dc.citation.spage413
dc.citation.epage426
dc.citation.other52(4): 413-426
dc.citation.rankM23
dc.identifier.wos000431691500001
dc.identifier.doi10.1180/claymin.2017.052.04.01
dc.identifier.scopus2-s2.0-85042654681
dc.identifier.rcubconv_4115
dc.type.versionpublishedVersion


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