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Fruit Wines Inhibitory Activity Against alpha-Glucosidase

Нема приказа
Аутори
Čakar, Uroš
Grozdanić, Nada
Petrović, Aleksandar V.
Pejin, Boris
Nastasijević, Branislav
Marković, Bojan
Đorđević, Brižita
Чланак у часопису (Објављена верзија)
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Апстракт
Background: Fruit wines are well known for their profound health-promoting properties including both enzyme activations and inhibitions. They may act preventive in regard to diabetes melitus and other chronic diseases. Objectives: Potential alpha-glucosidase inhibitory activity of fruit wines made from blueberry, black chokeberry, blackberry, raspberry and sour cherry was the subject of this study. Method: In order to increase the alcohol content due to enriched extraction of total phenolics, sugar was added in the fruit pomace of the half of the examined fruit wine samples. Results: Compared with acarbose used as a positive control (IC50 = 73.78 mu g/mL), all fruit wine samples exhibited higher alpha-glucosidase inhibitory activity. Indeed, blueberry wine samples stood out, both prepared with IC50 = 24.14 mu g/mL, lyophilised extract yield 3.23% and without IC50 = 46.39 mu g/mL, lyophilised extract yield 2.89% and with addition of sugar before fermentation. Chlorogenic acid predominan...tly contributed to alpha-glucosidase inhibitory activity of the blueberry, black chokeberry and sour cherry wine samples. However, ellagic acid, a potent alpha-glucosidase inhibitor possessing a planar structure, only slightly affected the activity of the blueberry wine samples, due to the lower concentration. In addition to this, molecular docking study of chlorogenic acid pointed out the importance of binding energy (-8.5 kcal/mol) for the inhibition of the enzyme. Conclusion: In summary, fruit wines made from blueberry should be primarily taken into consideration as a medicinal food targeting diabetes mellitus type 2 in the early stage, if additional studies would confirm their therapeutic potential for the control of postprandial hyperglycemia.

Извор:
Current Pharmaceutical Biotechnology, 2017, 18, 15, 1264-1272
Издавач:
  • Bentham Science Publ Ltd, Sharjah
Пројекти:
  • Развој и примена нових и традиционалних технологија у производњи конкурентних прехрамбених производа са додатом вредношћу за европско и светско тржиште - Створимо богатство из богатства Србије (RS-46001)

DOI: 10.2174/1389201019666180410112439

ISSN: 1389-2010

PubMed: 29637856

WoS: 000431242000005

Scopus: 2-s2.0-85052706990
[ Google Scholar ]
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5
URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2791
Колекције
  • Radovi istraživača / Researchers’ publications
Институција
Pharmacy

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