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dc.creatorČakar, Uroš
dc.creatorGrozdanić, Nada
dc.creatorPetrović, Aleksandar V.
dc.creatorPejin, Boris
dc.creatorNastasijević, Branislav
dc.creatorMarković, Bojan
dc.creatorĐorđević, Brižita
dc.date.accessioned2019-09-02T11:57:14Z
dc.date.available2019-09-02T11:57:14Z
dc.date.issued2017
dc.identifier.issn1389-2010
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2791
dc.description.abstractBackground: Fruit wines are well known for their profound health-promoting properties including both enzyme activations and inhibitions. They may act preventive in regard to diabetes melitus and other chronic diseases. Objectives: Potential alpha-glucosidase inhibitory activity of fruit wines made from blueberry, black chokeberry, blackberry, raspberry and sour cherry was the subject of this study. Method: In order to increase the alcohol content due to enriched extraction of total phenolics, sugar was added in the fruit pomace of the half of the examined fruit wine samples. Results: Compared with acarbose used as a positive control (IC50 = 73.78 mu g/mL), all fruit wine samples exhibited higher alpha-glucosidase inhibitory activity. Indeed, blueberry wine samples stood out, both prepared with IC50 = 24.14 mu g/mL, lyophilised extract yield 3.23% and without IC50 = 46.39 mu g/mL, lyophilised extract yield 2.89% and with addition of sugar before fermentation. Chlorogenic acid predominantly contributed to alpha-glucosidase inhibitory activity of the blueberry, black chokeberry and sour cherry wine samples. However, ellagic acid, a potent alpha-glucosidase inhibitor possessing a planar structure, only slightly affected the activity of the blueberry wine samples, due to the lower concentration. In addition to this, molecular docking study of chlorogenic acid pointed out the importance of binding energy (-8.5 kcal/mol) for the inhibition of the enzyme. Conclusion: In summary, fruit wines made from blueberry should be primarily taken into consideration as a medicinal food targeting diabetes mellitus type 2 in the early stage, if additional studies would confirm their therapeutic potential for the control of postprandial hyperglycemia.en
dc.publisherBentham Science Publ Ltd, Sharjah
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS//
dc.rightsrestrictedAccess
dc.sourceCurrent Pharmaceutical Biotechnology
dc.titleFruit Wines Inhibitory Activity Against alpha-Glucosidaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЧакар, Урош; Настасијевић, Бранислав; Петровић, Aлександар В.; Ђорђевић, Брижита; Пејин, Борис; Грозданић, Нада; Марковић, Бојан;
dc.citation.volume18
dc.citation.issue15
dc.citation.spage1264
dc.citation.epage1272
dc.citation.other18(15): 1264-1272
dc.citation.rankM23
dc.identifier.wos000431242000005
dc.identifier.doi10.2174/1389201019666180410112439
dc.identifier.pmid29637856
dc.identifier.scopus2-s2.0-85052706990
dc.identifier.rcubconv_4112
dc.type.versionpublishedVersion


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