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Serum Neutrophil Gelatinase-Associated Lipocalin and Urinary Kidney Injury Molecule-1 as Potential Biomarkers of Subclinical Nephrotoxicity After Gadolinium-Based and Iodinated-Based Contrast Media Exposure in Pediatric Patients with Normal Kidney Functio
dc.creator | Spasojević-Dimitrijeva, Brankica | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Dukić, Milan | |
dc.creator | Paripović, Dušan | |
dc.creator | Miloševski-Lomić, Gordana | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.creator | Pavicević, Polina | |
dc.creator | Mitrović, Jadranka | |
dc.creator | Kostić, Mirjana | |
dc.date.accessioned | 2019-09-02T11:57:19Z | |
dc.date.available | 2019-09-02T11:57:19Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1643-3750 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2793 | |
dc.description.abstract | Background: New renal biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) show promise in early diagnosis of contrast media induced acute kidney injury (CI-AKI). The purpose of our study was to compare the subclinical nephrotoxicity (a condition without changes in standard renal biomarkers) of gadolinium-based contrast media (Gd-DTPA, gadopentetate dimeglumine) and iodinated-based contrast media (iopromide) in pediatric patients with normal kidney function. Material/Methods: The first group (n=58) of patients included in the study were undergoing angiography with iopromide, and the second group (n=65) were undergoing magnetic resonance (MR) angiography/urography with Gd-DTPA administration. The concentrations of NGAL and KIM-1 were measured four times in the urine (pre-contrast, then at four hours, 24 hours, and 48 hours after contrast administration), and serum NGAL was measured at 0 (base-line), 24 hours, and 48 hours after contrast exposure. Results: After 24 hours, serum NGAL increase of >= 25% was noticed in 32.6% of the patients in the iopromide group and in 25.45% of the patients in the gadolinium group, with significantly higher average percent of this increase in first group (62.23% vs. 36.44%, p=0.002). In the Gd-DTPA group, we observed a statistically significant increase in urinary KIM-1 24 hours after the procedure. Normalized urinary KIM-1, 24 hours after contrast exposure, was a better predictive factor for CI-AKI than other biomarkers (AUC 0.757, cut off 214 pg/mg, sensitivity 83.3%, specificity 54.2%, p=0.035). Conclusions: In children with normal renal function, exposure to iodinated-based and gadolinium-based media might lead to subclinical nephrotoxicity, which could be detected using serum NGAL and urinary KIM-1. | en |
dc.publisher | Int Scientific Information, Inc, Melville | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS// | |
dc.rights | openAccess | |
dc.source | Medical Science Monitor | |
dc.subject | Acute Kidney Injury | en |
dc.subject | Child | en |
dc.subject | Contrast Media | en |
dc.subject | Gadolinium | en |
dc.title | Serum Neutrophil Gelatinase-Associated Lipocalin and Urinary Kidney Injury Molecule-1 as Potential Biomarkers of Subclinical Nephrotoxicity After Gadolinium-Based and Iodinated-Based Contrast Media Exposure in Pediatric Patients with Normal Kidney Functio | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Павицевић, Полина; Котур-Стевуљевић, Јелена; Костић, Мирјана; Дукић, Милан; Париповић, Душан; Спасојевић-Калимановска, Весна; Митровић, Јадранка; Милошевски-Ломић, Гордана; Спасојевић-Димитријева, Бранкица; | |
dc.citation.volume | 23 | |
dc.citation.other | 23: - | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000409268500001 | |
dc.identifier.doi | 10.12659/MSM.903255 | |
dc.identifier.pmid | 28874655 | |
dc.identifier.scopus | 2-s2.0-85029582185 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1432/2791.pdf | |
dc.type.version | publishedVersion |