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Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae)

Authorized Users Only
2017
Authors
Kolundžić, Marina
Stanojković, Tatjana
Radović, Jelena
Tačić, Ana
Dodevska, Margarita
Milenković, Marina
Sisto, Francesca
Masia, Carla
Farronato, Giampietro
Nikolić, Vesna D.
Kundaković, Tatjana
Article (Published version)
Metadata
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Abstract
Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of Cantharellus cibarius were tested. Broth microdilution assay was performed against 10 bacterial strains (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract was the most active against H. pylori strains with minimal inhibitory concentration values between 4 and 32 mu g/mL. All extracts were active against antibiotic resistant H. pylori. Methanol and aqueous extracts had no cytotoxicity against tested cell lines, whereas cyclohexane and dichloromethane extracts were active against HeLa and N87 cells, but also against healthy MRC-5 cells (IC50 39.26 +/- 1.24-134.79 +/- 0.01 mu g/mL). The tested aqueous extracts have shown 68% of angiotensin-converting enzyme inhibitory activity in doses of 1.25 mg/m...L. Chemical analysis has shown the presence of linoleic, cis-vaccenic, and oleic acids, sterols, beta-glucans, and polyphenolic compounds.

Keywords:
antibacterial activity / ACE inhibitory activity / beta-glucan / Cantharellus cibarius / cytotoxicity
Source:
Journal of Medicinal Food, 2017, 20, 8, 790-796
Publisher:
  • Mary Ann Liebert, Inc, New Rochelle
Funding / projects:
  • Investigation on the medicinal plants: morphological, chemical and pharmacological characterisation (RS-173021)

DOI: 10.1089/jmf.2016.0176

ISSN: 1096-620X

PubMed: 28613963

WoS: 000407429600009

Scopus: 2-s2.0-85027382116
[ Google Scholar ]
14
5
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/2798
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Kolundžić, Marina
AU  - Stanojković, Tatjana
AU  - Radović, Jelena
AU  - Tačić, Ana
AU  - Dodevska, Margarita
AU  - Milenković, Marina
AU  - Sisto, Francesca
AU  - Masia, Carla
AU  - Farronato, Giampietro
AU  - Nikolić, Vesna D.
AU  - Kundaković, Tatjana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2798
AB  - Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of Cantharellus cibarius were tested. Broth microdilution assay was performed against 10 bacterial strains (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract was the most active against H. pylori strains with minimal inhibitory concentration values between 4 and 32 mu g/mL. All extracts were active against antibiotic resistant H. pylori. Methanol and aqueous extracts had no cytotoxicity against tested cell lines, whereas cyclohexane and dichloromethane extracts were active against HeLa and N87 cells, but also against healthy MRC-5 cells (IC50 39.26 +/- 1.24-134.79 +/- 0.01 mu g/mL). The tested aqueous extracts have shown 68% of angiotensin-converting enzyme inhibitory activity in doses of 1.25 mg/mL. Chemical analysis has shown the presence of linoleic, cis-vaccenic, and oleic acids, sterols, beta-glucans, and polyphenolic compounds.
PB  - Mary Ann Liebert, Inc, New Rochelle
T2  - Journal of Medicinal Food
T1  - Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae)
VL  - 20
IS  - 8
SP  - 790
EP  - 796
DO  - 10.1089/jmf.2016.0176
ER  - 
@article{
author = "Kolundžić, Marina and Stanojković, Tatjana and Radović, Jelena and Tačić, Ana and Dodevska, Margarita and Milenković, Marina and Sisto, Francesca and Masia, Carla and Farronato, Giampietro and Nikolić, Vesna D. and Kundaković, Tatjana",
year = "2017",
abstract = "Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of Cantharellus cibarius were tested. Broth microdilution assay was performed against 10 bacterial strains (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract was the most active against H. pylori strains with minimal inhibitory concentration values between 4 and 32 mu g/mL. All extracts were active against antibiotic resistant H. pylori. Methanol and aqueous extracts had no cytotoxicity against tested cell lines, whereas cyclohexane and dichloromethane extracts were active against HeLa and N87 cells, but also against healthy MRC-5 cells (IC50 39.26 +/- 1.24-134.79 +/- 0.01 mu g/mL). The tested aqueous extracts have shown 68% of angiotensin-converting enzyme inhibitory activity in doses of 1.25 mg/mL. Chemical analysis has shown the presence of linoleic, cis-vaccenic, and oleic acids, sterols, beta-glucans, and polyphenolic compounds.",
publisher = "Mary Ann Liebert, Inc, New Rochelle",
journal = "Journal of Medicinal Food",
title = "Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae)",
volume = "20",
number = "8",
pages = "790-796",
doi = "10.1089/jmf.2016.0176"
}
Kolundžić, M., Stanojković, T., Radović, J., Tačić, A., Dodevska, M., Milenković, M., Sisto, F., Masia, C., Farronato, G., Nikolić, V. D.,& Kundaković, T.. (2017). Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae). in Journal of Medicinal Food
Mary Ann Liebert, Inc, New Rochelle., 20(8), 790-796.
https://doi.org/10.1089/jmf.2016.0176
Kolundžić M, Stanojković T, Radović J, Tačić A, Dodevska M, Milenković M, Sisto F, Masia C, Farronato G, Nikolić VD, Kundaković T. Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae). in Journal of Medicinal Food. 2017;20(8):790-796.
doi:10.1089/jmf.2016.0176 .
Kolundžić, Marina, Stanojković, Tatjana, Radović, Jelena, Tačić, Ana, Dodevska, Margarita, Milenković, Marina, Sisto, Francesca, Masia, Carla, Farronato, Giampietro, Nikolić, Vesna D., Kundaković, Tatjana, "Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae)" in Journal of Medicinal Food, 20, no. 8 (2017):790-796,
https://doi.org/10.1089/jmf.2016.0176 . .

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