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Cytotoxic and Antimicrobial Activities of Cantharellus cibarius Fr. (Cantarellaceae)

Authorized Users Only
2017
Authors
Kolundžić, Marina
Stanojković, Tatjana
Radović, Jelena
Tačić, Ana
Dodevska, Margarita
Milenković, Marina
Sisto, Francesca
Masia, Carla
Farronato, Giampietro
Nikolić, Vesna D.
Kundaković, Tatjana
Article (Published version)
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Abstract
Antibacterial and cytotoxic activities of cyclohexane, dichloromethane, methanol, and aqueous extracts of Cantharellus cibarius were tested. Broth microdilution assay was performed against 10 bacterial strains (Staphylococcus aureus, S. epidermidis, Micrococcus luteus, Bacillus subtilis, Enterococcus feacalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella abony), with emphasis on Helicobacter pylori. Methanol extract was the most active against H. pylori strains with minimal inhibitory concentration values between 4 and 32 mu g/mL. All extracts were active against antibiotic resistant H. pylori. Methanol and aqueous extracts had no cytotoxicity against tested cell lines, whereas cyclohexane and dichloromethane extracts were active against HeLa and N87 cells, but also against healthy MRC-5 cells (IC50 39.26 +/- 1.24-134.79 +/- 0.01 mu g/mL). The tested aqueous extracts have shown 68% of angiotensin-converting enzyme inhibitory activity in doses of 1.25 mg/m...L. Chemical analysis has shown the presence of linoleic, cis-vaccenic, and oleic acids, sterols, beta-glucans, and polyphenolic compounds.

Keywords:
antibacterial activity / ACE inhibitory activity / beta-glucan / Cantharellus cibarius / cytotoxicity
Source:
Journal of Medicinal Food, 2017, 20, 8, 790-796
Publisher:
  • Mary Ann Liebert, Inc, New Rochelle
Projects:
  • Investigation on the medicinal plants: morphological, chemical and pharmacological characterisation (RS-173021)

DOI: 10.1089/jmf.2016.0176

ISSN: 1096-620X

PubMed: 28613963

WoS: 000407429600009

Scopus: 2-s2.0-85027382116
[ Google Scholar ]
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2798
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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