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Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women
dc.creator | Klisić, Aleksandra | |
dc.creator | Kavarić, Nebojša | |
dc.creator | Jovanović, Milovan | |
dc.creator | Soldatović, Ivan | |
dc.creator | Gligorović-Barhanović, Najdana | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.date.accessioned | 2019-09-02T11:57:29Z | |
dc.date.available | 2019-09-02T11:57:29Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1734-1922 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2800 | |
dc.description.abstract | Introduction: Previous studies have examined the correlation between hyperandrogenemia and non-alcoholic fatty liver disease (NAFLD) in women and showed contradictory results. Therefore, we aimed to evaluate the relationship between testosterone level and Fatty Liver Index (FLI), as a surrogate marker for NAFLD, in a cohort of postmenopausal women. Material and methods: A total of 150 postmenopausal women were included in this cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure, were obtained. Non-alcoholic fatty liver disease is assessed by FLI, an algorithm based on body mass index, waist circumference, triglycerides and gamma-glutamyl transferase, as a simple and accurate predictor of hepatic steatosis. Women were divided into three groups (FLI lt 30, n = 80; 30 = FLI lt 60, n = 44; FLI = 60, n = 26). Homeostasis model assessment of insulin resistance (HOMA-IR) as a surrogate marker of insulin resistance was calculated. Results: Multiple linear regression analysis revealed that the best model consisted of 4 parameters (e.g., bioavailable testosterone (beta = 0.288, p = 0.001), log HOMA-IR (beta = 0.227, p = 0.005), log high-sensitivity C-reactive protein (beta = 0.322, p lt 0.001), and retinol-binding protein 4 (beta = 0.226, p lt 0.001)). Adjusted R-2 for the best model was 0.550, which means that as much as 55.0% of variation in FLI could be explained with this model. Conclusions: Bioavailable testosterone is independently associated with FLI in postmenopausal women. | en |
dc.publisher | Termedia Publishing House Ltd, Poznan | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.source | Archives of Medical Science | |
dc.title | Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women | en |
dc.type | article | |
dc.rights.license | BY-NC-SA | |
dcterms.abstract | Каварић, Небојша; Јовановић, Милован; Солдатовић, Иван; Глигоровић-Бархановић, Најдана; Клисић, Aлександра; Котур-Стевуљевић, Јелена; | |
dc.citation.volume | 13 | |
dc.citation.issue | 5 | |
dc.citation.spage | 1188 | |
dc.citation.epage | 1196 | |
dc.citation.other | 13(5): 1188-1196 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000407270200023 | |
dc.identifier.doi | 10.5114/aoms.2017.68972 | |
dc.identifier.pmid | 28883861 | |
dc.identifier.scopus | 2-s2.0-85026831104 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs//bitstream/id/1438/2798.pdf | |
dc.type.version | publishedVersion |