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Influence of different wild-garlic (Allium ursinum) extracts on the gastrointestinal system: spasmolytic, antimicrobial and antioxidant properties

Authorized Users Only
2017
Authors
Pavlović, Dragana R.
Veljković, Milica
Stojanović, Nikola M.
Gocmanac-Ignjatović, Marija
Mihailov-Krstev, Tatjana
Branković, Suzana
Sokolović, Dušan
Marčetić, Mirjana
Radulović, Niko
Radenković, Mirjana
Article (Published version)
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Abstract
ObjectivesAs there are no previous studies of the European wild-garlic (Allium ursinum) effects on the gastrointestinal system, despite its traditional applications in gastrointestinal disorders' treatment and regular use in the human diet, we have quantified and compared spasmolytic, antimicrobial and antioxidant activities of its different leaf extracts. MethodsWild-garlic extracts were tested for spasmolytic activity on isolated rat ileum, antimicrobial activity on selected Gram-positive and Gram-negative bacteria and fungi by microdilution method and antioxidant capacity by DPPH radical-scavenging assay. Key findingsWild-garlic extracts were found to decrease ileal basal tone. As the relaxation of K+-induced contractions was similar to one caused by papaverin, the observed spasmolytic effect was most likely mediated through Ca2+-channel inhibition. Ethanolic extract (with the highest phenolic and high alk(en)yl cysteine sulphoxides' levels) produced the strongest spasmolytic activi...ty. In case of acetylcholine-induced contractions, only hydromethanolic extract showed no statistical difference in comparison with positive control. All samples exhibited certain antioxidant potential and strong antimicrobial activity against tested enteropathogenic strains (Salmonella enteritidis was the most sensitive, followed by Escherichia coli, Proteus mirabilis and Enterococcus faecalis). ConclusionBesides other already established health-promoting effects, wild garlic could be useful in treatment of mild gastrointestinal disturbances.

Keywords:
Allium ursinum / enteropathogenic strains / qNMR of alk(en)yl cysteine sulphoxides / rat ileum / spasmolytic activity
Source:
Journal of Pharmacy and Pharmacology, 2017, 69, 9, 1208-1218
Publisher:
  • Wiley, Hoboken
Projects:
  • Preventive, therapeutic, and ethical approach in preclinical and clinical studies of the genes and modulators of redox cell signaling in immune, inflammatory and proliferative cell response (RS-41018)

DOI: 10.1111/jphp.12746

ISSN: 0022-3573

PubMed: 28543032

WoS: 000407083000014

Scopus: 2-s2.0-85019619634
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2802
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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