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dc.creatorPavlović, Dragana R.
dc.creatorVeljković, Milica
dc.creatorStojanović, Nikola M.
dc.creatorGocmanac-Ignjatović, Marija
dc.creatorMihailov-Krstev, Tatjana
dc.creatorBranković, Suzana
dc.creatorSokolović, Dušan
dc.creatorMarčetić, Mirjana
dc.creatorRadulović, Niko
dc.creatorRadenković, Mirjana
dc.date.accessioned2019-09-02T11:57:31Z
dc.date.available2019-09-02T11:57:31Z
dc.date.issued2017
dc.identifier.issn0022-3573
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2802
dc.description.abstractObjectivesAs there are no previous studies of the European wild-garlic (Allium ursinum) effects on the gastrointestinal system, despite its traditional applications in gastrointestinal disorders' treatment and regular use in the human diet, we have quantified and compared spasmolytic, antimicrobial and antioxidant activities of its different leaf extracts. MethodsWild-garlic extracts were tested for spasmolytic activity on isolated rat ileum, antimicrobial activity on selected Gram-positive and Gram-negative bacteria and fungi by microdilution method and antioxidant capacity by DPPH radical-scavenging assay. Key findingsWild-garlic extracts were found to decrease ileal basal tone. As the relaxation of K+-induced contractions was similar to one caused by papaverin, the observed spasmolytic effect was most likely mediated through Ca2+-channel inhibition. Ethanolic extract (with the highest phenolic and high alk(en)yl cysteine sulphoxides' levels) produced the strongest spasmolytic activity. In case of acetylcholine-induced contractions, only hydromethanolic extract showed no statistical difference in comparison with positive control. All samples exhibited certain antioxidant potential and strong antimicrobial activity against tested enteropathogenic strains (Salmonella enteritidis was the most sensitive, followed by Escherichia coli, Proteus mirabilis and Enterococcus faecalis). ConclusionBesides other already established health-promoting effects, wild garlic could be useful in treatment of mild gastrointestinal disturbances.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41018/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Pharmacy and Pharmacology
dc.subjectAllium ursinumen
dc.subjectenteropathogenic strainsen
dc.subjectqNMR of alk(en)yl cysteine sulphoxidesen
dc.subjectrat ileumen
dc.subjectspasmolytic activityen
dc.titleInfluence of different wild-garlic (Allium ursinum) extracts on the gastrointestinal system: spasmolytic, antimicrobial and antioxidant propertiesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтојановић, Никола М.; Марчетић, Мирјана; Раденковић, Мирјана; Вељковић, Милица; Радуловић, Нико; Бранковић, Сузана; Михаилов-Крстев, Татјана; Павловић, Драгана Р.; Гоцманац-Игњатовић, Марија; Соколовић, Душан;
dc.citation.volume69
dc.citation.issue9
dc.citation.spage1208
dc.citation.epage1218
dc.citation.other69(9): 1208-1218
dc.citation.rankM22
dc.identifier.wos000407083000014
dc.identifier.doi10.1111/jphp.12746
dc.identifier.pmid28543032
dc.identifier.scopus2-s2.0-85019619634
dc.type.versionpublishedVersion


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