Show simple item record

dc.creatorHeck, Rouven
dc.creatorLukić, Milica
dc.creatorSavić, Snežana
dc.creatorDaniels, Rolf
dc.creatorLunter, Dominique
dc.date.accessioned2019-09-02T11:57:37Z
dc.date.available2019-09-02T11:57:37Z
dc.date.issued2017
dc.identifier.issn0928-0987
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2806
dc.description.abstractAim: The purpose of this study was to evaluate skin permeation and penetration of nonivamide which has been formulated in novel film-forming formulations (FFFs). These formulations aim to prolong the availability of capsaicinoids which are used in long-term treatment of chronic pruritus. Methods: An oily solution of nonivamide was loaded into porous silica particles which then were suspended in an aqueous dispersion of a sustained release polymer. Permeation and penetration experiments were performed ex vivo with postauricular porcine skin using modified Franz diffusion cells. The penetrated drug amount was assessed ex vivo by skin surface biopsy followed by cryo-sectioning. Furthermore, in vivo skin irritation experiments were performed to compare the potential skin irritation caused by the FFFs to conventionally used semi-solid formulations. Results: Permeation rates of nonivamide from FFF through the skin are comparable to that from clinically used immediate release formulations. This elucidates the therapeutic safety profile of the novel FFF. Penetration studies confirmed the prolonged drug availability at the site of action. FFFs were found not to irritate the skin of healthy volunteers. Conclusion: FFFs with sustained nonivamide penetration represent safe and easy-to-use formulations. They therefore may improve the treatment of chronic pruritus with capsaicinoids by enhancing patient compliance through a sustained release regime.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationEuropean Social Fund
dc.relationMinistry of Science, Research and the Arts Baden-Wuerttemberg
dc.relationGerman Academic Exchange Service (DAAD)
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmaceutical Sciences
dc.subjectChronic pruritusen
dc.subjectFilm-forming formulationsen
dc.subjectNonivamideen
dc.subjectPorous silicaen
dc.subjectSkin penetration & permeationen
dc.titleEx vivo skin permeation and penetration of nonivamide from and in vivo skin tolerability of film-forming formulations containing porous silicaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДаниелс, Ролф; Хецк, Роувен; Савић, Снежана; Лунтер, Доминиqуе; Лукић, Милица;
dc.citation.volume106
dc.citation.spage34
dc.citation.epage40
dc.citation.other106: 34-40
dc.citation.rankM21
dc.identifier.wos000406988600004
dc.identifier.doi10.1016/j.ejps.2017.05.045
dc.identifier.pmid28546105
dc.identifier.scopus2-s2.0-85019848868
dc.identifier.rcubconv_3905
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record