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dc.creatorToljić, Mina
dc.creatorEgić, Amira
dc.creatorMunjas, Jelena
dc.creatorOrlić, Nataša Karadzov
dc.creatorMilovanović, Zagorka
dc.creatorRadenković, Aleksandra
dc.creatorVuceljić, Jovana
dc.creatorJoksić, Ivana
dc.date.accessioned2019-09-02T11:57:42Z
dc.date.available2019-09-02T11:57:42Z
dc.date.issued2017
dc.identifier.issn0890-6238
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/2808
dc.description.abstractWe investigated whether gestational diabetes mellitus (GDM) and gestational arterial hypertension (GH) are associated with increased oxidative stress and DNA damage. Study included 3 groups of pregnant women (GDM, GH and control). DNA damage biomarkers (micronuclei MNi, nucleoplasmic bridges NPBs and nuclear buds NBUDs) were assessed by cytokinesis-block micronucleus cytome assay. Oxidative stress levels were evaluated by analyzing malondialdehyde equivalents (TBARS) and 8-hydroxy-2'deoxyguanosine (8-OHdG). Genotoxic effect of methyldopa, drug used to treat GH, was evaluated in in vitro experiment. TBARS levels, MNi, NPBs and NBUDs frequencies were significantly increased in both GDM and GH group. Concentrations of 8-OHdG were significantly higher in GDM than in other groups. Since methyldopa did not affect MNi, NPBs and NBUDs frequencies, nor TBARS and 8-OHdG levels, we concluded that methyldopa has no genotoxic effect. Thus, even when hyperglycemia or hypertension are present only during pregnancy they induce oxidative stress, DNA damage and chromosomal aberrations.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173046/RS//
dc.rightsrestrictedAccess
dc.sourceResearch in Microbiology
dc.subjectGestational diabetes mellitusen
dc.subjectGestational arterial hypertensionen
dc.subjectOxidative stressen
dc.subjectMicronucleien
dc.subjectCytokinesis-block micronucleus cytome assayen
dc.subjectMalondialdehydeen
dc.subject8-Hydroxy-2'-deoxyguanosineen
dc.subjectMethyldopaen
dc.titleIncreased oxidative stress and cytokinesis-block micronucleus cytome assay parameters in pregnant women with gestational diabetes mellitus and gestational arterial hypertensionen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРаденковић, Aлександра; Миловановић, Загорка; Муњас, Јелена; Тољић, Мина; Егић, Aмира; Орлић, Наташа Карадзов; Јоксић, Ивана; Вуцељић, Јована;
dc.citation.volume71
dc.citation.spage55
dc.citation.epage62
dc.citation.other71: 55-62
dc.citation.rankM22
dc.identifier.wos000406736600006
dc.identifier.doi10.1016/j.reprotox.2017.04.002
dc.identifier.pmid28400286
dc.identifier.scopus2-s2.0-85018649006
dc.type.versionpublishedVersion


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