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dc.creatorVezmar-Kovačević, Sandra
dc.creatorMiljković, Branislava
dc.creatorĆulafić, Milica
dc.creatorKovačević, Milena
dc.creatorGolubović, Bojana
dc.creatorJovanović, Marija
dc.creatorVučićević, Katarina
dc.creatorde Gier, Johan J.
dc.date.accessioned2019-09-02T11:57:44Z
dc.date.available2019-09-02T11:57:44Z
dc.date.issued2017
dc.identifier.issn1356-1294
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2811
dc.description.abstractAims and Objectives Targeting older patients with predictive factors for drug-related problems (DRPs) could make clinical medication reviews more cost-effective. The aim of this study was to identify the number, type, and potential predictive factors for DRPs in older polypharmacy patients. Methods Community pharmacists performed clinical medication reviews and documented DRPs, types of interventions, and their implementation in older patients. Results Three hundred eighty-eight medication reviews were analyzed, 964 DRPs (average 2.51.9), and 1022 interventions (average 2.6 +/- 2.0) were identified. The overall implementation rate of interventions was 70.1%, the highest was observed in interventions aiming to resolve the lack of therapy monitoring (86.8%). Patients with 12 medications had an increased risk of 5 DRPs (P lt .001). Asthma was associated with lack of adherence (P = .002), lack of aspirin, statins, and proton pump inhibitors use with additional therapy needed (P = .002-.004). Predictive factors for drug interactions were antihypertensive medications and/or medications with narrow therapeutic index (P lt .05). Lack of efficacy was associated with diabetes (P = .006). Nonsteroidal anti-inflammatory drugs were risk factors for inappropriate drug selection (P = .002). Lack of monitoring was associated with hypertension (P = .013), whereas benzodiazepines (P lt .001) and aspirin (P = .021) were overused. Conclusion Patients with asthma, hypertension, and diabetes and lack of statin, antithrombotic agent, and/or proton pump inhibitor use were associated with higher risks for DRPs.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175023/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Evaluation in Clinical Practice
dc.subjectclinical medication reviewen
dc.subjectcommunity pharmacyen
dc.subjectdrug-related problemsen
dc.subjectolder patientsen
dc.subjectpolypharmacyen
dc.titleEvaluation of drug-related problems in older polypharmacy primary care patientsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВезмар-Ковачевић, Сандра; Голубовић, Бојана; Вучићевић, Катарина; Ћулафић, Милица; де Гиер, Јохан Ј.; Миљковић, Бранислава; Ковачевић, Милена; Јовановић, Марија;
dc.citation.volume23
dc.citation.issue4
dc.citation.spage860
dc.citation.epage865
dc.citation.other23(4): 860-865
dc.citation.rankM22
dc.identifier.wos000406299200024
dc.identifier.doi10.1111/jep.12737
dc.identifier.pmid28370742
dc.identifier.scopus2-s2.0-85016600235
dc.identifier.rcubconv_3901
dc.type.versionpublishedVersion


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