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Alterations of HDL Particles in Children with End-Stage Renal Disease

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2017
2813.pdf (80.65Kb)
Authors
Stefanović, Aleksandra
Ristovski-Kornić, Danijela
Kotur-Stevuljević, Jelena
Spasojević-Kalimanovska, Vesna
Vekić, Jelena
Miljković, Milica
Paripović, Dušan
Peco-Antić, Amira
Jelić-Ivanović, Zorana
Zeljković, Aleksandra
Article (Published version)
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Abstract
Background: Unfavorable lipid profile presents one of most important risk factor for cardiovascular disease in renal pathology. Myeloperoxidase (MPO) as enzyme which oxidizes lipoproteins and paraoxonase1 (PON1) as anti-oxidative enzyme have been involved in pathogenesis of cardiovascular disease. In the present study we sought to assess oxidative stress status, lipoprotein subclasses distribution as well as functionality of high density lipoprotein (HDL) trough MPO/PON1 ratio in children with chronic kidney disease (CKD) and children after renal transplantation. Methods: PON1 activity and oxidative stress parameters were measured spectrophotometrically, while MPO concentration was determined using immunoassay. Separation of lipoprotein subclasses was performed by vertical gradient gel electrophoresis in 19 children with different stage of CKD and 19 post-transplantation patients (PT). Results: CKD patients had increased MPO/PON1 ratio and higher prevalence of smaller HDL subclasses wh...en compared to PT subjects. Also, there was a significant positive correlation between MPO level and MPO/PON1 ratio with relative proportion of smaller HDL subclasses. Conclusions: Children with CKD have impaired HDL distribution that is improved after kidney transplantation. Since that measurement of HDL distribution and functionality arenot routinely available, MPO/PON1 ratio may be useful marker that could provide necessary information.

Keywords:
chronic kidney disease / HDL particles / myeloperoxidase
Source:
Journal of Medical Biochemistry, 2017, 36, 4, 358-365
Publisher:
  • Društvo medicinskih biohemičara Srbije, Beograd i Versita
Projects:
  • Interactive role of dyslipidemia, oxidative stress and inflammation in atherosclerosis and other diseases: genetic and biochemical markers (RS-175035)

DOI: 10.1515/jomb-2017-0019

ISSN: 1452-8258

PubMed: 30581333

WoS: 000408878600009

Scopus: 2-s2.0-85029396541
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2815
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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