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dc.creatorStefanović, Aleksandra
dc.creatorRistovski-Kornić, Danijela
dc.creatorKotur-Stevuljević, Jelena
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorVekić, Jelena
dc.creatorMiljković, Milica
dc.creatorParipović, Dušan
dc.creatorPeco-Antić, Amira
dc.creatorJelić-Ivanović, Zorana
dc.creatorZeljković, Aleksandra
dc.date.accessioned2019-09-02T11:57:51Z
dc.date.available2019-09-02T11:57:51Z
dc.date.issued2017
dc.identifier.issn1452-8258
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2815
dc.description.abstractBackground: Unfavorable lipid profile presents one of most important risk factor for cardiovascular disease in renal pathology. Myeloperoxidase (MPO) as enzyme which oxidizes lipoproteins and paraoxonase1 (PON1) as anti-oxidative enzyme have been involved in pathogenesis of cardiovascular disease. In the present study we sought to assess oxidative stress status, lipoprotein subclasses distribution as well as functionality of high density lipoprotein (HDL) trough MPO/PON1 ratio in children with chronic kidney disease (CKD) and children after renal transplantation. Methods: PON1 activity and oxidative stress parameters were measured spectrophotometrically, while MPO concentration was determined using immunoassay. Separation of lipoprotein subclasses was performed by vertical gradient gel electrophoresis in 19 children with different stage of CKD and 19 post-transplantation patients (PT). Results: CKD patients had increased MPO/PON1 ratio and higher prevalence of smaller HDL subclasses when compared to PT subjects. Also, there was a significant positive correlation between MPO level and MPO/PON1 ratio with relative proportion of smaller HDL subclasses. Conclusions: Children with CKD have impaired HDL distribution that is improved after kidney transplantation. Since that measurement of HDL distribution and functionality arenot routinely available, MPO/PON1 ratio may be useful marker that could provide necessary information.en
dc.publisherDruštvo medicinskih biohemičara Srbije, Beograd i Versita
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.sourceJournal of Medical Biochemistry
dc.subjectchronic kidney diseaseen
dc.subjectHDL particlesen
dc.subjectmyeloperoxidaseen
dc.titleAlterations of HDL Particles in Children with End-Stage Renal Diseaseen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПецо-Aнтић, Aмира; Векић, Јелена; Стефановић, Aлександра; Спасојевић-Калимановска, Весна; Јелић-Ивановић, Зорана; Миљковић, Милица; Зељковић, Aлександра; Котур-Стевуљевић, Јелена; Париповић, Душан; Ристовски-Корнић, Данијела;
dc.citation.volume36
dc.citation.issue4
dc.citation.spage358
dc.citation.epage365
dc.citation.other36(4): 358-365
dc.citation.rankM23
dc.identifier.wos000408878600009
dc.identifier.doi10.1515/jomb-2017-0019
dc.identifier.pmid30581333
dc.identifier.scopus2-s2.0-85029396541
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1451/2813.pdf
dc.identifier.rcubconv_3932
dc.type.versionpublishedVersion


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