Development of semisolid self-microemulsifying drug delivery systems (SMEDDSs) filled in hard capsules for oral delivery of aciclovir
Само за регистроване кориснике
2017
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The study aimed to develop semisolid self-microemulsifying drug delivery systems (SMEDDSs) as carriers for oral delivery of aciclovir in hard hydroxypropylmethyl cellulose (HPMC) capsules. Six selfdispersing systems (SD1-SD6) were prepared by loading aciclovir into the semisolid formulations consisting of medium chain length triglycerides (lipid), macrogolglycerol hydroxystearate (surfactant), polyglyceryl-3-dioleate (cosurfactant), glycerol (hydrophilic cosolvent), and macrogol 8000 (viscosity modifier). Their characterization was performed in order to identify the semisolid system with rheological behaviour suitable for filling in hard HPMC capsules and fast dispersibility in acidic and alkaline aqueous media with formation of oil-in-water microemulsions. The optimal SMEDDS was loaded with aciclovir at two levels (2% and 33.33%) and morphology and aqueous dispersibility of the obtained systems were examined by applying light microscopy and photon correlation spectroscopy (PCS), respe...ctively. The assessment of diffusivity of aciclovir from the SMEDDSs by using an enhancer cell model, showed that it was increased at a higher drug loading. Differential scanning calorimetry (DSC) analysis indicated that the SMEDDSs were semisolids at temperatures up to 50 degrees C and physically stable and compatible with HPMC capsules for 3 months storage at 25 degrees C and 4 degrees C. The results of in vitro release study revealed that the designed solid dosage form based on the semisolid SMEDDS loaded with the therapeutic dose of 200 mg, may control partitioning of the solubilized drug from in situ formed oil-inwater microemulsion carrier into the sorrounding aqueous media, and hence decrease the risk for precipitation of the drug.
Кључне речи:
Self-microemulsifying drug delivery systems (SMEDDS) / Aciclovir / Macrogol 8000 / Rheological behaviour / Photon correlation spectroscopy (PCS) / Differential scanning calorimetry (DSC) / In vitro drug releaseИзвор:
International Journal of Pharmaceutics, 2017, 528, 1-2, 372-380Издавач:
- Elsevier Science BV, Amsterdam
Финансирање / пројекти:
DOI: 10.1016/j.ijpharm.2017.06.028
ISSN: 0378-5173
PubMed: 28619449
WoS: 000408007600034
Scopus: 2-s2.0-85020764437
Институција/група
PharmacyTY - JOUR AU - Đekić, Ljiljana AU - Janković, Jovana AU - Čalija, Bojan AU - Primorac, Marija PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2825 AB - The study aimed to develop semisolid self-microemulsifying drug delivery systems (SMEDDSs) as carriers for oral delivery of aciclovir in hard hydroxypropylmethyl cellulose (HPMC) capsules. Six selfdispersing systems (SD1-SD6) were prepared by loading aciclovir into the semisolid formulations consisting of medium chain length triglycerides (lipid), macrogolglycerol hydroxystearate (surfactant), polyglyceryl-3-dioleate (cosurfactant), glycerol (hydrophilic cosolvent), and macrogol 8000 (viscosity modifier). Their characterization was performed in order to identify the semisolid system with rheological behaviour suitable for filling in hard HPMC capsules and fast dispersibility in acidic and alkaline aqueous media with formation of oil-in-water microemulsions. The optimal SMEDDS was loaded with aciclovir at two levels (2% and 33.33%) and morphology and aqueous dispersibility of the obtained systems were examined by applying light microscopy and photon correlation spectroscopy (PCS), respectively. The assessment of diffusivity of aciclovir from the SMEDDSs by using an enhancer cell model, showed that it was increased at a higher drug loading. Differential scanning calorimetry (DSC) analysis indicated that the SMEDDSs were semisolids at temperatures up to 50 degrees C and physically stable and compatible with HPMC capsules for 3 months storage at 25 degrees C and 4 degrees C. The results of in vitro release study revealed that the designed solid dosage form based on the semisolid SMEDDS loaded with the therapeutic dose of 200 mg, may control partitioning of the solubilized drug from in situ formed oil-inwater microemulsion carrier into the sorrounding aqueous media, and hence decrease the risk for precipitation of the drug. PB - Elsevier Science BV, Amsterdam T2 - International Journal of Pharmaceutics T1 - Development of semisolid self-microemulsifying drug delivery systems (SMEDDSs) filled in hard capsules for oral delivery of aciclovir VL - 528 IS - 1-2 SP - 372 EP - 380 DO - 10.1016/j.ijpharm.2017.06.028 ER -
@article{ author = "Đekić, Ljiljana and Janković, Jovana and Čalija, Bojan and Primorac, Marija", year = "2017", abstract = "The study aimed to develop semisolid self-microemulsifying drug delivery systems (SMEDDSs) as carriers for oral delivery of aciclovir in hard hydroxypropylmethyl cellulose (HPMC) capsules. Six selfdispersing systems (SD1-SD6) were prepared by loading aciclovir into the semisolid formulations consisting of medium chain length triglycerides (lipid), macrogolglycerol hydroxystearate (surfactant), polyglyceryl-3-dioleate (cosurfactant), glycerol (hydrophilic cosolvent), and macrogol 8000 (viscosity modifier). Their characterization was performed in order to identify the semisolid system with rheological behaviour suitable for filling in hard HPMC capsules and fast dispersibility in acidic and alkaline aqueous media with formation of oil-in-water microemulsions. The optimal SMEDDS was loaded with aciclovir at two levels (2% and 33.33%) and morphology and aqueous dispersibility of the obtained systems were examined by applying light microscopy and photon correlation spectroscopy (PCS), respectively. The assessment of diffusivity of aciclovir from the SMEDDSs by using an enhancer cell model, showed that it was increased at a higher drug loading. Differential scanning calorimetry (DSC) analysis indicated that the SMEDDSs were semisolids at temperatures up to 50 degrees C and physically stable and compatible with HPMC capsules for 3 months storage at 25 degrees C and 4 degrees C. The results of in vitro release study revealed that the designed solid dosage form based on the semisolid SMEDDS loaded with the therapeutic dose of 200 mg, may control partitioning of the solubilized drug from in situ formed oil-inwater microemulsion carrier into the sorrounding aqueous media, and hence decrease the risk for precipitation of the drug.", publisher = "Elsevier Science BV, Amsterdam", journal = "International Journal of Pharmaceutics", title = "Development of semisolid self-microemulsifying drug delivery systems (SMEDDSs) filled in hard capsules for oral delivery of aciclovir", volume = "528", number = "1-2", pages = "372-380", doi = "10.1016/j.ijpharm.2017.06.028" }
Đekić, L., Janković, J., Čalija, B.,& Primorac, M.. (2017). Development of semisolid self-microemulsifying drug delivery systems (SMEDDSs) filled in hard capsules for oral delivery of aciclovir. in International Journal of Pharmaceutics Elsevier Science BV, Amsterdam., 528(1-2), 372-380. https://doi.org/10.1016/j.ijpharm.2017.06.028
Đekić L, Janković J, Čalija B, Primorac M. Development of semisolid self-microemulsifying drug delivery systems (SMEDDSs) filled in hard capsules for oral delivery of aciclovir. in International Journal of Pharmaceutics. 2017;528(1-2):372-380. doi:10.1016/j.ijpharm.2017.06.028 .
Đekić, Ljiljana, Janković, Jovana, Čalija, Bojan, Primorac, Marija, "Development of semisolid self-microemulsifying drug delivery systems (SMEDDSs) filled in hard capsules for oral delivery of aciclovir" in International Journal of Pharmaceutics, 528, no. 1-2 (2017):372-380, https://doi.org/10.1016/j.ijpharm.2017.06.028 . .