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The Role of Oxidative Stress in the Clinical Manifestations of Childhood Asthma

Authorized Users Only
2017
Authors
Topić, Aleksandra
Francuski, Đorđe
Nikolić, Aleksandra
Milošević, Katarina
Jovičić, Snežana
Marković, Bojan
Đukić, Mirjana
Radojković, Dragica
Article (Published version)
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Abstract
Introduction: The significance of oxidative stress in pathogenesis of childhood asthma was recognized, but its role in the clinical manifestations of disease is still unclear. Materials and Methods: The study was conducted in 96 asthmatic children. The urinary biomarker of oxidative stress, 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG/creatinine) was determined by using HPLC-MS/MS. ELISA was performed to measure myeloperoxidase (MPO) and Cu,Zn-superoxide dismutase (Cu, Zn-SOD) in serum. Results: Logistic regression analysis revealed that female gender, tobacco smoke exposure, and increased 8-oxodG/creatinine were associated with risk for intermittent asthma, while the positive allergy test and increased Cu, Zn-SOD were associated with eczema in asthmatic children. Higher MPO (p = 0.033), and percent of granulocytes (p = 0.030) were found in severe persistent asthma in comparison to intermittent or mild persistent asthma. Conclusion: The main findings that TSE-induced oxidative stress is... a risk for intermittent asthma and eczema may be clinically significant for the disease prevention and therapeutic improvements.

Source:
Fetal and Pediatric Pathology, 2017, 36, 4, 294-303
Publisher:
  • Taylor & Francis Inc, Philadelphia
Projects:
  • Complex diseases as a model system for phenotype modulation- structural and functional analysis of molecular biomarkers (RS-173008)

DOI: 10.1080/15513815.2017.1315199

ISSN: 1551-3815

PubMed: 28481134

WoS: 000416502700004

Scopus: 2-s2.0-85019046891
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URI
http://farfar.pharmacy.bg.ac.rs/handle/123456789/2833
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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