Show simple item record

dc.creatorBuha, Aleksandra
dc.creatorWallace, David
dc.creatorMatović, Vesna
dc.creatorSchweitzer, Amie
dc.creatorOluić, Branislav
dc.creatorMicić, Dušan
dc.creatorĐorđević, Vladimir
dc.date.accessioned2019-09-02T11:58:19Z
dc.date.available2019-09-02T11:58:19Z
dc.date.issued2017
dc.identifier.issn2314-6133
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2836
dc.description.abstractAlthough profoundly studied, etiology of pancreatic cancer (PC) is still rather scant. Exposure to cadmium (Cd), a ubiquitous metal associated with well-established toxic and carcinogenic properties, has been hypothesized to one putative cause of PC. Hence, we analyzed recently published observational studies, meta-analyses, and experimental animal and in vitro studies with the aim of summarizing the evidence of Cd involvement in PC development and describing the possible mechanisms. Consolidation of epidemiological data on PC and exposure to Cd indicated a significant association with an elevated risk of PC among general population exposed to Cd. Cadmium exposure of laboratory animals was showed to cause PC supporting the findings suggested by human studies. The concordance with human and animal studies is buttressed by in vitro studies, although in vitro data interpretation is problematic. In most instances, only significant effects are reported, and the concentrations of Cd are excessive, which would skew interpretation. Previous reports suggest that oxidative stress, apoptotic changes, and DNA cross-linking and hypermethylation are involved in Cd-mediated carcinogenesis. Undoubtedly, a significant amount of work is still needed to achieve a better understanding of the Cd involvement in pancreatic cancer which could facilitate prevention, diagnosis, and therapy of this fatal disease.en
dc.publisherHindawi Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.rightsopenAccess
dc.sourceBiomed Research International
dc.titleCadmium Exposure as a Putative Risk Factor for the Development of Pancreatic Cancer: Three Different Lines of Evidenceen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractБуха, Aлександра; Сцхwеитзер, Aмие; Олуић, Бранислав; Мицић, Душан; Wаллаце, Давид; Ђорђевић, Владимир; Матовић, Весна;
dc.citation.rankM22
dc.identifier.wos000415379600001
dc.identifier.doi10.1155/2017/1981837
dc.identifier.pmid29349066
dc.identifier.scopus2-s2.0-85042214191
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1468/2834.pdf
dc.identifier.rcubconv_3992
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record