The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report
Samo za registrovane korisnike
2017
Autori
Kuburović, VladimirVekić, Jelena
Zeljković, Aleksandra
Carrie, Alain
Kotur-Stevuljević, Jelena
Bojanin, Dragana
Kosutić, Jovan
Spasojević-Kalimanovska, Vesna
Miljković, Milica
Kuburović, Nina
Couvert, Philippe
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Objective: Plasma high-density lipoprotein cholesterol (HDL-C) level is a strong inverse predictor of cardiovascular disease (CVD) development. Tangier disease, a consequence of mutations in the ATP binding cassette transporter 1 (ABCA1) gene, is associated with very low HDL-C levels. Still, the relationship between Tangier disease and CVD is not always evident. The study investigates usefulness of lipoprotein subfractions, oxidative stress and paraoxonase 1 (PON1) status assessment for evaluation and management of patient with low HDL-C phenotype. Patient and methods: A 12-year-old boy was hospitalised due to hypertension. Laboratory evaluation revealed low HDL-C level, and subsequent molecular diagnostic confirmed Tangier disease. Lipoprotein subfractions were assessed by gradient-gel electrophoresis. Oxidative stress status was estimated by measuring total antioxidative status, total oxidative status, prooxidative-antioxidative balance, malondialdehyde and advanced oxidation protein... products levels. Activity of paraoxonase 1 in serum and its distribution within HDL subclasses was also determined (ten healthy boys aged 13.1 +/- 3.4 years served as the reference group). Results: Analysis of oxidative stress status biomarkers revealed a state of prolonged prooxidants activity. In turn, serum PON1 activity was substantially reduced. The majority of PON1 activity was present on HDL 2 particles. Conclusion: Impaired antioxidative potential of HDL may point toward hidden cardiovascular risk in isolated low HDL-phenotype.
Ključne reči:
Tangier disease / Oxidative stress / Small, dense LDL / HDL subclasses / PON1 statusIzvor:
Clinical Biochemistry, 2017, 50, 18, 1323-1325Izdavač:
- Pergamon-Elsevier Science Ltd, Oxford
Finansiranje / projekti:
- Interaktivna uloga dislipidemije, oksidativnog stresa i inflamacije u aterosklerozi i drugim bolestima: genetički i biohemijski markeri (RS-MESTD-Basic Research (BR or ON)-175035)
DOI: 10.1016/j.clinbiochem.2017.06.007
ISSN: 0009-9120
PubMed: 28648695
WoS: 000415987300055
Scopus: 2-s2.0-85021131934
Institucija/grupa
PharmacyTY - JOUR AU - Kuburović, Vladimir AU - Vekić, Jelena AU - Zeljković, Aleksandra AU - Carrie, Alain AU - Kotur-Stevuljević, Jelena AU - Bojanin, Dragana AU - Kosutić, Jovan AU - Spasojević-Kalimanovska, Vesna AU - Miljković, Milica AU - Kuburović, Nina AU - Couvert, Philippe PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2840 AB - Objective: Plasma high-density lipoprotein cholesterol (HDL-C) level is a strong inverse predictor of cardiovascular disease (CVD) development. Tangier disease, a consequence of mutations in the ATP binding cassette transporter 1 (ABCA1) gene, is associated with very low HDL-C levels. Still, the relationship between Tangier disease and CVD is not always evident. The study investigates usefulness of lipoprotein subfractions, oxidative stress and paraoxonase 1 (PON1) status assessment for evaluation and management of patient with low HDL-C phenotype. Patient and methods: A 12-year-old boy was hospitalised due to hypertension. Laboratory evaluation revealed low HDL-C level, and subsequent molecular diagnostic confirmed Tangier disease. Lipoprotein subfractions were assessed by gradient-gel electrophoresis. Oxidative stress status was estimated by measuring total antioxidative status, total oxidative status, prooxidative-antioxidative balance, malondialdehyde and advanced oxidation protein products levels. Activity of paraoxonase 1 in serum and its distribution within HDL subclasses was also determined (ten healthy boys aged 13.1 +/- 3.4 years served as the reference group). Results: Analysis of oxidative stress status biomarkers revealed a state of prolonged prooxidants activity. In turn, serum PON1 activity was substantially reduced. The majority of PON1 activity was present on HDL 2 particles. Conclusion: Impaired antioxidative potential of HDL may point toward hidden cardiovascular risk in isolated low HDL-phenotype. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Clinical Biochemistry T1 - The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report VL - 50 IS - 18 SP - 1323 EP - 1325 DO - 10.1016/j.clinbiochem.2017.06.007 ER -
@article{ author = "Kuburović, Vladimir and Vekić, Jelena and Zeljković, Aleksandra and Carrie, Alain and Kotur-Stevuljević, Jelena and Bojanin, Dragana and Kosutić, Jovan and Spasojević-Kalimanovska, Vesna and Miljković, Milica and Kuburović, Nina and Couvert, Philippe", year = "2017", abstract = "Objective: Plasma high-density lipoprotein cholesterol (HDL-C) level is a strong inverse predictor of cardiovascular disease (CVD) development. Tangier disease, a consequence of mutations in the ATP binding cassette transporter 1 (ABCA1) gene, is associated with very low HDL-C levels. Still, the relationship between Tangier disease and CVD is not always evident. The study investigates usefulness of lipoprotein subfractions, oxidative stress and paraoxonase 1 (PON1) status assessment for evaluation and management of patient with low HDL-C phenotype. Patient and methods: A 12-year-old boy was hospitalised due to hypertension. Laboratory evaluation revealed low HDL-C level, and subsequent molecular diagnostic confirmed Tangier disease. Lipoprotein subfractions were assessed by gradient-gel electrophoresis. Oxidative stress status was estimated by measuring total antioxidative status, total oxidative status, prooxidative-antioxidative balance, malondialdehyde and advanced oxidation protein products levels. Activity of paraoxonase 1 in serum and its distribution within HDL subclasses was also determined (ten healthy boys aged 13.1 +/- 3.4 years served as the reference group). Results: Analysis of oxidative stress status biomarkers revealed a state of prolonged prooxidants activity. In turn, serum PON1 activity was substantially reduced. The majority of PON1 activity was present on HDL 2 particles. Conclusion: Impaired antioxidative potential of HDL may point toward hidden cardiovascular risk in isolated low HDL-phenotype.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Clinical Biochemistry", title = "The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report", volume = "50", number = "18", pages = "1323-1325", doi = "10.1016/j.clinbiochem.2017.06.007" }
Kuburović, V., Vekić, J., Zeljković, A., Carrie, A., Kotur-Stevuljević, J., Bojanin, D., Kosutić, J., Spasojević-Kalimanovska, V., Miljković, M., Kuburović, N.,& Couvert, P.. (2017). The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report. in Clinical Biochemistry Pergamon-Elsevier Science Ltd, Oxford., 50(18), 1323-1325. https://doi.org/10.1016/j.clinbiochem.2017.06.007
Kuburović V, Vekić J, Zeljković A, Carrie A, Kotur-Stevuljević J, Bojanin D, Kosutić J, Spasojević-Kalimanovska V, Miljković M, Kuburović N, Couvert P. The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report. in Clinical Biochemistry. 2017;50(18):1323-1325. doi:10.1016/j.clinbiochem.2017.06.007 .
Kuburović, Vladimir, Vekić, Jelena, Zeljković, Aleksandra, Carrie, Alain, Kotur-Stevuljević, Jelena, Bojanin, Dragana, Kosutić, Jovan, Spasojević-Kalimanovska, Vesna, Miljković, Milica, Kuburović, Nina, Couvert, Philippe, "The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report" in Clinical Biochemistry, 50, no. 18 (2017):1323-1325, https://doi.org/10.1016/j.clinbiochem.2017.06.007 . .