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dc.creatorKuburović, Vladimir
dc.creatorVekić, Jelena
dc.creatorZeljković, Aleksandra
dc.creatorCarrie, Alain
dc.creatorKotur-Stevuljević, Jelena
dc.creatorBojanin, Dragana
dc.creatorKosutić, Jovan
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorMiljković, Milica
dc.creatorKuburović, Nina
dc.creatorCouvert, Philippe
dc.date.accessioned2019-09-02T11:58:26Z
dc.date.available2019-09-02T11:58:26Z
dc.date.issued2017
dc.identifier.issn0009-9120
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/2840
dc.description.abstractObjective: Plasma high-density lipoprotein cholesterol (HDL-C) level is a strong inverse predictor of cardiovascular disease (CVD) development. Tangier disease, a consequence of mutations in the ATP binding cassette transporter 1 (ABCA1) gene, is associated with very low HDL-C levels. Still, the relationship between Tangier disease and CVD is not always evident. The study investigates usefulness of lipoprotein subfractions, oxidative stress and paraoxonase 1 (PON1) status assessment for evaluation and management of patient with low HDL-C phenotype. Patient and methods: A 12-year-old boy was hospitalised due to hypertension. Laboratory evaluation revealed low HDL-C level, and subsequent molecular diagnostic confirmed Tangier disease. Lipoprotein subfractions were assessed by gradient-gel electrophoresis. Oxidative stress status was estimated by measuring total antioxidative status, total oxidative status, prooxidative-antioxidative balance, malondialdehyde and advanced oxidation protein products levels. Activity of paraoxonase 1 in serum and its distribution within HDL subclasses was also determined (ten healthy boys aged 13.1 +/- 3.4 years served as the reference group). Results: Analysis of oxidative stress status biomarkers revealed a state of prolonged prooxidants activity. In turn, serum PON1 activity was substantially reduced. The majority of PON1 activity was present on HDL 2 particles. Conclusion: Impaired antioxidative potential of HDL may point toward hidden cardiovascular risk in isolated low HDL-phenotype.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourceClinical Biochemistry
dc.subjectTangier diseaseen
dc.subjectOxidative stressen
dc.subjectSmall, dense LDLen
dc.subjectHDL subclassesen
dc.subjectPON1 statusen
dc.titleThe usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case reporten
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦоуверт, Пхилиппе; Зељковић, Aлександра; Кубуровић, Нина; Косутић, Јован; Бојанин, Драгана; Царрие, Aлаин; Кубуровић, Владимир; Спасојевић-Калимановска, Весна; Векић, Јелена; Котур-Стевуљевић, Јелена; Миљковић, Милица;
dc.citation.volume50
dc.citation.issue18
dc.citation.spage1323
dc.citation.epage1325
dc.citation.other50(18): 1323-1325
dc.citation.rankM22
dc.identifier.wos000415987300055
dc.identifier.doi10.1016/j.clinbiochem.2017.06.007
dc.identifier.pmid28648695
dc.identifier.scopus2-s2.0-85021131934
dc.identifier.rcubconv_3996
dc.type.versionpublishedVersion


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