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The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report
dc.creator | Kuburović, Vladimir | |
dc.creator | Vekić, Jelena | |
dc.creator | Zeljković, Aleksandra | |
dc.creator | Carrie, Alain | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Bojanin, Dragana | |
dc.creator | Kosutić, Jovan | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.creator | Miljković, Milica | |
dc.creator | Kuburović, Nina | |
dc.creator | Couvert, Philippe | |
dc.date.accessioned | 2019-09-02T11:58:26Z | |
dc.date.available | 2019-09-02T11:58:26Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0009-9120 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/2840 | |
dc.description.abstract | Objective: Plasma high-density lipoprotein cholesterol (HDL-C) level is a strong inverse predictor of cardiovascular disease (CVD) development. Tangier disease, a consequence of mutations in the ATP binding cassette transporter 1 (ABCA1) gene, is associated with very low HDL-C levels. Still, the relationship between Tangier disease and CVD is not always evident. The study investigates usefulness of lipoprotein subfractions, oxidative stress and paraoxonase 1 (PON1) status assessment for evaluation and management of patient with low HDL-C phenotype. Patient and methods: A 12-year-old boy was hospitalised due to hypertension. Laboratory evaluation revealed low HDL-C level, and subsequent molecular diagnostic confirmed Tangier disease. Lipoprotein subfractions were assessed by gradient-gel electrophoresis. Oxidative stress status was estimated by measuring total antioxidative status, total oxidative status, prooxidative-antioxidative balance, malondialdehyde and advanced oxidation protein products levels. Activity of paraoxonase 1 in serum and its distribution within HDL subclasses was also determined (ten healthy boys aged 13.1 +/- 3.4 years served as the reference group). Results: Analysis of oxidative stress status biomarkers revealed a state of prolonged prooxidants activity. In turn, serum PON1 activity was substantially reduced. The majority of PON1 activity was present on HDL 2 particles. Conclusion: Impaired antioxidative potential of HDL may point toward hidden cardiovascular risk in isolated low HDL-phenotype. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS// | |
dc.rights | restrictedAccess | |
dc.source | Clinical Biochemistry | |
dc.subject | Tangier disease | en |
dc.subject | Oxidative stress | en |
dc.subject | Small, dense LDL | en |
dc.subject | HDL subclasses | en |
dc.subject | PON1 status | en |
dc.title | The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Цоуверт, Пхилиппе; Зељковић, Aлександра; Кубуровић, Нина; Косутић, Јован; Бојанин, Драгана; Царрие, Aлаин; Кубуровић, Владимир; Спасојевић-Калимановска, Весна; Векић, Јелена; Котур-Стевуљевић, Јелена; Миљковић, Милица; | |
dc.citation.volume | 50 | |
dc.citation.issue | 18 | |
dc.citation.spage | 1323 | |
dc.citation.epage | 1325 | |
dc.citation.other | 50(18): 1323-1325 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000415987300055 | |
dc.identifier.doi | 10.1016/j.clinbiochem.2017.06.007 | |
dc.identifier.pmid | 28648695 | |
dc.identifier.scopus | 2-s2.0-85021131934 | |
dc.type.version | publishedVersion |